CAS: 875-59-2; 1-(4-Hydroxy-2-Methylphenyl)Ethanone

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CAS号122-46-3 乙酸间甲苯酯 | CAS号64-19-7 冰醋酸 | CAS号108-39-4 间甲酚 | CAS号140-39-6 乙酸对甲苯酯 | CAS号64299-71-4 4-Phenylsulfiny... | CAS号59414-23-2 1-甲氧基-3-(三甲基硅氧基... | CAS号108-24-7 乙酸酐 | CAS号100-84-5 间甲基苯甲醚 | CAS号75-36-5 乙酰氯 | CAS号6921-64-8 2'-羟基-4'-甲基苯乙酮 | CAS号3470-49-3 5-羟基-1-茚酮 | CAS号6921-64-8 2'-羟基-4'-甲基苯乙酮 | CAS号108-39-4 间甲酚 | CAS号252561-46-9 (4-acetyl-3-met... | CAS号74331-69-4 1-乙炔基-4-甲氧基-2-甲基苯 | CAS号578-39-2 4-羟基-2-甲基苯甲酸 | CAS号122-46-3 乙酸间甲苯酯 | CAS号1123-94-0 4-ethyl-m-cresol | CAS号24826-74-2 1-(4-甲氧基-2-甲基苯基)乙酮 | CAS号22574-58-9 4-(hydroxymethy...

乙酸间甲苯酯置于三氯化铝体系中,用 硝基苯 作为反应溶剂,化学反应生成 4'-羟基-2'-甲基苯乙酮
参考文献:替代效应.v. Dmso 中苯酚的氢键羟基质子的 NMR 化学位移
标题:替代效应.v. Dmso 中苯酚的氢键羟基质子的 NMR 化学位移
摘要:在 Dmso 中测定了 M-和 P-取代苯酚以及 4-取代 2-甲酚,3-甲酚和 2,6-二甲苯酚的氢键 Oh 质子的化学位移.取代基对这些系列的羟基化学位移的影响彼此线性相关(相关系数> 0.999),除了 3-甲酚系列中庞大的平面取代基可能会受到它们与苯环.用方程δδ=ρ(σ0+r-δ\barσr-)成功地处理了取代基效应.苯酚系列给出 R-=0.673 和 ρ=1.530.相同的 R-值似乎适用于所有其他系列,而 ρ 值的变化可以忽略不计.偏离特定取代基的相关性,特别是那些具有酸性氢的取代基,
DOI:10.1246/bcsj.48.2127

专利信息

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:EP-0729465-B1
优先权日:1993-11-19
标 题:Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:PARKE DAVIS & CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof