专利号:US-10538790-B2 优先权日:2016-04-04 标题 :Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents 发明人:KAVARANA MALCOLM J; PEET RICHARD C 权利人:TEEWINOT TECH LIMITED 摘要:The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.
专利号:US-5674729-A 优先权日:1991-06-24 标 题 :De novo cell-free synthesis of picornavirus 发明人:WIMMER ECKARD; MOLLA AKHTERUZZAMAN; PAUL ANIKO V 权利人:UNIV NEW YORK STATE RES FOUND 摘要:A process for the de novo synthesis of a picornavirus using a cell-free medium has been developed. The cell-free medium is prepared from a lysate of mammalian cells from which the nuclei and mitochondria has been removed, endogenous mRNA deactivated and supplemented with nucleoside triphosphates, tRNA, amino acids and precursors necessary for generating proteins. The genomic RNA of the picornavirus or rhinovirus is added to the cell-free medium and after incubation at about 30° C. to 40° C. of from about 4 to 24 hours infectious, mature virus particles are formed.
专利号:US-2025043248-A1 优先权日:2023-08-04 标题:Preparation method and use of hydrogel material for growth of blood vessel organoids 发明人:SUN DI; SUN JIAMING; WANG ZHENXING; LEI SHIZE 权利人:UNION HOSPITAL TONGJI MEDICAL COLLEGE HUST 摘要:The present disclosure provides a preparation method and use of a hydrogel material for growth of blood vessel organoids (BVOs). The preparation method of the hydrogel material includes: (1) synthesis of gelatin methacryloyl (GelMA), and (2) synthesis of ns-GelMA-PEO. The hydrogel material may be used for in vitro cultivation of BVOs. The hydrogel material ns-GelMA-PEO prepared by the present disclosure may significantly improve the survival and budding abilities of BVOs. The ns-GelMA-PEO provides a novel solution for in vitro cultivation of BVOs, and may well support the growth and differentiation of organoids.
专利号:US-9657030-B2 优先权日:2010-06-11 标 题 :Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof 发明人:GIGUERE JOSHUA ROBERT; MCCARTHY KEITH EDWARD; REISCH HELGE ALFRED; SANDOVAL SERGIO; STYMIEST JAKE LARRY 权利人:RHODES TECH 摘要:The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
专利号:US-4639360-A 优先权日:1985-10-28 标题 :Synthesis of crystalline silicate ZSM-5 using an organic sulfonic acid 发明人:VALYOCSIK ERNEST W 权利人:MOBIL OIL CORP 摘要:This invention relates to a new form of crystalline silicate identified as zeolite ZSM-5, to a new and useful improvement in synthesizing said crystalline silicate and to use of said crystalline silicate prepared in accordance herewith as a catalyst for organic compound, e.g. hydrocarbon compound, conversion.
专利号:US-7387884-B2 优先权日:2003-01-07 标 题 :Yeast extract solution for cell-free protein synthesis, method for preparation thereof and method for cell-free protein synthesis using same 发明人:SUZUKI TAKASHI; EZURE TORU; ITO MASAAKI 权利人:SHIMADZU CORP 摘要:The present invention provides a preparation method of a yeast extract solution for cell-free protein synthesis, which solution is easy to prepare and is capable of synthesizing a higher amount of a protein than by conventional yeast extract solutions, the yeast extract solution, a cell-free synthesis method of protein, which uses the yeast extract solution, and a kit for cell-free protein synthesis containing the yeast extract solution. The method of the present invention includes rupturing a yeast cell in a frozen state, and obtaining an extract thereof.
1: Bocanegra-Jiménez FY, Montero-Morán GM, Lara-González S. Purification and characterization of an FeII- and α-ketoglutarate-dependent xanthine hydroxylase from Aspergillus oryzae. Protein Expr Purif. 2021 Mar 11:105862. doi: 10.1016/j.pep.2021.105862. Epub ahead of print. 28(1):15-26. doi: 10.21315/mjms2021.28.1.3. Epub 2021 Feb 24. 5: Brudar S, Hribar-Lee B. Effect of Buffer on Protein Stability in Aqueous Solutions: A Simple Protein Aggregation Model. J Phys Chem B. 2021 Mar 18;125(10):2504-2512. doi: 10.1021/acs.jpcb.0c10339. Epub 2021 Mar 3.
合成参考文献
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