CAS: 62561-76-6; (R)-2-Amino-3-(Thiophen-2-yl)Propanoic Acid

该化合物是一种合成的peptide衍生物,具有硫基组,是五人组成的含硫磺的环环化合物,其特点是其独特的结构包括D-alaine残留物,有助于其潜在的生物活动;二二二甲酸蜜的存在可加强其与生物目标的互动,使其对医药化学和药理业感兴趣.通常,这种化合物是根据其在生物过程调节中的作用,包括其作为...

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2021-58-1 130309-35-2 22951-96-8

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合成工艺路线路线简述

  • 合成目标产物 D-2-Thienylalanine 主要起始原料 2-Thiophenemethanol
  • (文献来源)合成步骤主要原料 2-Thiophenemethanol
📜(+/-)-2-(Chloroacetyl-Amino)-3-[2]Thienyl-Propionic Acid置于氢溴酸体系中,化学反应生成 3-(2-噻吩基)-D-丙氨酸
参考文献:Studies On The Chemistry Of Heterocyclics. Viii. Enzymatic Resolution Of Racemic β-2-Thienylalanine And Preparation Of Some Substituted β-2-Thienylalanines1
标题:Studies On The Chemistry Of Heterocyclics. Viii. Enzymatic Resolution Of Racemic β-2-Thienylalanine And Preparation Of Some Substituted β-2-Thienylalanines1
摘要:
DOI:10.1021/jo01149A040

海关参考信息

专利信息


专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人:GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:EP-4041249-A1
优先权日:2019-10-10
标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:CN-114761026-A
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of non-natural polypeptides

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1138.

合成参考文献


摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 408.
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