CAS: 605-65-2; 5-(Dimethylamino)Naphthalene-1-Sulfonyl Chloride

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CAS号4272-77-9 丹酰酸 | CAS号84-89-9 5-氨基-1-萘磺酸 | CAS号110232-19-4 5-(dimethylamin... | CAS号1101-67-3 丹磺酰-L-谷氨酰胺 | CAS号110232-20-7 5-(dimethylamin... | CAS号1101-68-4 (2S)-2-[[5-(dim... | CAS号35060-08-3 5-二甲基氨基萘-1-(n-(... | CAS号33008-06-9 丹磺酰肼 | CAS号34523-28-9 丹磺酰氟 | CAS号34068-01-4 3-苄氧基苯乙酮 | CAS号35021-16-0 丹磺酰-L-苏氨酸哌啶盐 | CAS号5354-61-0 丹西酰胺基乙硫醇

5-二甲氨基-1-萘磺酸置于氯化亚砜,N,N-二甲基甲酰胺体系中,化学反应生成 丹酰氯
参考文献:磺胺类:一类抑制动力 I Gtp 酶和网格蛋白介导的内吞作用的芳基磺酰胺,在动物模型中具有抗癫痫作用
标题:磺胺类:一类抑制动力 I Gtp 酶和网格蛋白介导的内吞作用的芳基磺酰胺,在动物模型中具有抗癫痫作用
摘要:我们发现,Dansylcadaverine (1) 是一种已知的网格蛋白介导的内吞作用 (Cme) 细胞内抑制剂,可适度抑制 U2Os 细胞中的动力蛋白 I (Dyni) Gtp 酶活性 (Ic 50 45 μm) 和转铁蛋白 (Tfn) 内吞作用 (Ic 50 205 μm)).合成了一类新型 Gtp 竞争性动力抑制剂,Sulfonadyns™.末端肉桂基部分的引入极大地增强了 Dyni 抑制.丹酰基和肉桂基部分之间的刚性二胺或酰胺连接不利于 Dyni 抑制.体外抑制 Dyni 活性的化合物 <10 Id=15> 例如类似物33 ((E)-N-(6-{[(3-(4-溴苯基)-2-丙烯-1-基]氨基}己基)-5-异喹啉磺酰胺)) 和47 个((E)-N-(3-{[3-(4-溴苯基)-2-丙烯-1-基]氨基}丙基)-1-萘磺酰胺)异构体,显示出 Dyn Ic 50 <4
DOI:10.1039/d2Md00371F

专利信息

专利号:US-2023235372-A1
优先权日:2020-06-12
标题:Ab-initio, template-independent synthesis of nucleic acids using thermostable enzymes
发明人：RANDRIANJATOVO-GBALOU IRINA; SAID AHMED; RAHIER RENAUD
权利人:SYNHELIX
摘要:The invention relates to the field of nucleic acid synthesis or sequencing, more specifically to methods for ab-initio synthesis of nucleic acids, comprising contacting a nucleotide with a free 3′-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3′-hydroxyl group of the nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of both ab-initio single-stranded nucleic acid synthesis activity and template-independent terminal nucleotidyl transferase activity.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-6048975-A
优先权日:1991-09-12
标 题:Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:A process for the chemical synthesis of oligonucleotides n Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-12139504-B2
优先权日:2022-08-09
标 题:Vanadium alkylidene complex, synthesis and use thereof
发明人：BUKHRYAKOV KONSTANTIN; BELOV DMITRY
权利人:BUKHRYAKOV KONSTANTIN; BELOV DMITRY; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe 3 )(PEt 3 ) 2 Cl, which exhibits superior performance compared to other analogs.

专利号:US-5945524-A
优先权日:1990-09-14
标 题 :Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.