专利号:US-2025188502-A1 优先权日:2022-03-10 标 题 :Biocatalyst and method for the synthesis of ubrogepant intermediates 发明人:CHEN HAIBIN; HU HU; CAI BAOQIN; XU JUNPENG; LIU SITONG; JIN LUPING; WU XINWEI; CUI QINYAN; ZHANG CHENGXIAO; ZHU KAILONG 权利人:ENZYMASTER NINGBO BIO ENG CO LTD 摘要:This application provides engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. This application also provides a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.
专利号:US-8519133-B2 优先权日:2009-06-11 标 题 :Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer 发明人:GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W 权利人:GROTE CHRISTOPHER W; CANTRELL GARY L; MCCLURG JOSEPH P; THOMASSON CATHERINE E; MOSER FRANK W; MALLINCKRODT LLC 摘要:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
专利号:WO-2023169184-A1 优先权日:2022-03-10 标 题:Biocatalyst and method for the synthesis of ubrogepant intermediates
专利号:EA-002100-B1 优先权日:1996-12-23 标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK
专利号:CN-117425728-A 优先权日:2022-03-10 标 题 :Biocatalysts and methods for the synthesis of Ubujipan intermediates
专利号:EP-1403278-A1 优先权日:2003-09-30 标题 :Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril