CAS: 58626-38-3; 2,5-Dioxopyrrolidin-1-Yl 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Benzoate

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CAS号5672-89-9 三氟乙酸N-琥珀酰亚胺酯 | CAS号36847-92-4 3-[[(2Z)-3-carb... | CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号17057-07-7 3-(2,5-二氧代-2,5-... | CAS号108-31-6 顺酐 | CAS号99-05-8 间氨基苯甲酸

📜3-[[(2Z)-3-Carboxy-1-Oxo-2-Propen-1-Yl]Amino]Benzoic Acid置于sodium Acetate,乙酸酐,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 5.17H,反应生成 3-马来酰亚胺基苯甲酸琥珀酰亚胺酯
参考文献:Augustin,Manfred; Mueller,Wolfgang,Journal Fur Praktische Chemie (Leipzig 1954),1985,Vol. 327,# 5,P. 789-798
标题:Augustin,Manfred; Mueller,Wolfgang,Journal Fur Praktische Chemie (Leipzig 1954),1985,Vol. 327,# 5,P. 789-798

专利信息

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

专利号:WO-2005040408-A1
优先权日:2003-10-22
标 题 :Method for the identification of enzymes having desired properties by immobilisation of the reaction product on the surface of enzyme-presenting organisms
发明人：KOLMAR HARALD
权利人:SELECORE GMBH; KOLMAR HARALD
摘要:The invention relates to a method for the identification of enzymes with a desired activity, by random generation of a large collection of enzyme variants, the synthesis of said variants in host organisms, the presentation thereof on the surface of the organisms and the isolation of enzyme variants with the desired properties, by the detection of the covalent deposition of the reaction product on the surface of the host organism.

专利号:US-10537106-B2
优先权日:2012-01-31
标题:Direct detection of disease biomarkers in clinical specimens using cationic nanoparticle-based assays and versatile and green methods for synthesis of anisotropic silver nanostructures
发明人：AZZAZY HASSAN MOHAMED EL-SAID; SHAWKY ABDUO SHERIF MOHAMED; EID KAMEL ABDELMENEM MOHAMED; GUIRGIS BASSEM SAMY SHENOUDA
权利人:AMERICAN UNIV IN CAIRO AUC
摘要:A gold nanoparticle-based assay for the detection of a target molecule, such as Hepatitis C Virus (HCV) RNA in serum samples, that uses positively charged gold nanoparticles (AuNPs) in solution based format. The assay has been tested on 74 serum clinical samples suspected of containing HCV RNA, with 48 and 38 positive and negative samples respectively. The developed assay has a specificity and sensitivity of 96.5% and 92.6% respectively. The results obtained were confirmed by Real-Time PCR, and a concordance of 100% for the negative samples and 89% for the positive samples has been obtained between the Real-Time PCR and the developed AuNPs based assay. Also, a purification method for the HCV RNA has been developed using HCV RNA specific probe conjugated to homemade silica nanoparticles. These silica nanoparticles have been synthesized by modified Stober method. This purification method enhanced the specificity of the developed AuNPs assay. The method can detect a target molecule, such as HCV RNA in serum, by employing modified silica nanoparticles to capture the target from a biological sample followed by detection of the captured target molecule using positively charged AuNPs. The assay is simple, cheap, sensitive and specific. Another aspect of the invention is anisotropic silver nanoparticles and methods of their use.

专利号:US-4795828-A
优先权日:1983-01-03
标题 :Functionalized intermediate for the synthesis of alpha-functionalized derivatives and labeled conjugates of procaimamide and NAPA
发明人：BUCKLER ROBERT T; WARD FREDERICK E
权利人:MILES INC
摘要:Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the alpha -position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are alpha -position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.

专利号:US-9012648-B2
优先权日:2012-08-21
标题 :Haptens of risperidone and paliperidone
发明人：HASPESLAGH PIETER RIK; VLIEGEN MAARTEN; HRYHORENKO ERIC; DECORY THOMAS R; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.