CAS: 533-98-2; 1,2-Dibromobutane

该化合物是一种有机化合物,分类为二溴烷,具体而言,是一种丁烷衍生物,在第一和第二碳位置上替换了两个溴原子.分子式为C4H8BR2,表明存在四个碳原子,八个氢原子和两个溴原子.该化合物一般是一种无色的,具有特质味的黄色淡液,其含量相对稠密,与非溴化的同类物相比,其沸点较高,原因是溴的存在增加了分子重量和中间分子力.1,2-二溴丁烷在诸如醚和氯仿等有机溶剂中可溶性,但在水中可溶性有限.它经常用于有机合成中,作为生产各种化学化合物的中间体,包括制药和农用化学品.然而,必须小心地处理该物质,因为溴化化合物可能具有危险性,并可能构成环境风险.在实验室环境中与1,在与1,2-二溴丁烷合作时,应当注意适当的安全措施.

英文名称1,2-Dibromobutane
中文名称1,2-二溴丁烷
IUPAC名称1,2-dibromobutane
其它别名(?à)-1,2-Dibromobutane; 1,2-Dibromobutane; a-Butylene dibromide
CAS编号533-98-2
MFCD编号:MFCD00000157
EINECS号:208-581-4
FDA UNII编号:8471F50VJI
分子式:C4H8Br2
分子量:215.91
产品CID: 1518860
产品分类有机原料→通用试剂→有机通用试剂

相似结构搜索
产品信息参考;;
InChIKey: CZWSZZHGSNZRMW-UHFFFAOYNA-N
InChI=1/C4H8Br2/c1-2-4(6)3-5/h4H,2-3H2,1H3…
计算化学: 氢键受体数*氢键供体数0.0可旋转键数2.0

相似化合物

1809-10-5 96-11-7 626-87-9

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
危险等级6.1(b)
UN编号2810
危险品标志Xi,Xn
包装等级III
安全声明37/39-26
危险类别码36/38-36/37/38-20/21/22
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

(S)-2-Bromo-Butan-1-Ol置于三溴化磷体系中,化学反应生成 1,2-二溴丁烷
参考文献:三溴化磷和亚硫酰溴将某些溴代醇转化为二溴化物的空间过程
标题:三溴化磷和亚硫酰溴将某些溴代醇转化为二溴化物的空间过程
摘要:(S)-(-)-2-溴-1-丁醇用sobr 2,Sobr 2-吡啶转化为1,2-二溴丁烷.研究了pbr 3.尽管与sobr 2的反应产生的二溴化物具有低的比旋光(在不存在吡啶时为正,在吡啶存在下为负),但pbr 3产生的左旋产物具有更高的旋光性.在4-叔丁基环己烯反式双轴溴代醇与sobr 2和sobr 2-吡啶,而与pbr 3的反应中获得反式-二溴化物的平衡混合物二溴化物的双轴率超过90%.从数据可以推断出(-)-1,2-二溴丁烷几乎可以肯定地具有(S)构型.在二氢辛可宁存在下1-丁烯的不对称溴化得到右旋的1,2-二溴丁烷.
DOI:10.1016/s0040-4020(01)82952-5

海关参考信息

2903310000-1,2-二溴乙烷
2903399020-溴甲烷
2901100000-饱和无环烃
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4297506-A
优先权日:1980-01-08
标题 :Synthesis of esters
发明人：COWAN KIPLIN D
权利人:PHILLIPS PETROLEUM CO
摘要:An organic ester is produced by conversion of an organic halide employing excess alkali metal carboxylate. A resultant reaction mass including solids comprised of alkali metal halide is obtained containing occluded in the solids portion an amount of otherwise difficult-to-recover desired ester product. At least a portion of said solids is recycled to the conversion whereby to prevent further occlusion of desired product. In an embodiment of the invention, potassium acetate salt is recycled for reuse.

专利号:US-2011092706-A1
优先权日:2009-10-21
标题 :Process for the manufacture of enantiomerically pure aryloctanoic acids as aliskiren
发明人：SOUKUP MILAN
权利人:CarboDesign LLC
摘要:The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, a novel bicyclic compound of formula IV.

专利号:US-3829522-A
优先权日:1971-10-21
标题:Synthesis of alkynes by dehydrohalogenation
发明人：SCHNEIDER C
权利人:SHERWIN WILLIAMS CO
摘要:MIXTURE AS A CONDENSED LIQUID. THE ALKYNE PRODUCTS ARE OBTAINED IN HIGH YEILD. A PROCESS FOR PREPARING ALKYNES OF HIGH PURITY BY DEHYDROGENATION. HALOGENATED PRECURSORS CONSISTING OF DIHALOALKANES AND MONOHALOALKENES ARE REACTED WITH PARTIAL ALCOHOLATE OF AN ALKALI METAL AND AN ALIPHATIC POLYOL. THE REACTION MIXTURE REMAINS FLUID DURING THE PROCESS. ALKYNES AND VOLATILE BY-PRODUCTS ARE EVAPORATED FROM THE REACTION MIXTURE AND PARTIALLY CONDENSED IN A SEPARATION TO RECOVER THE HIGH-PURITY ALKYNE PRODUCT. THE VOLATILE BY-PRODUCTS ARE RETURNED TO THE REACTION

专利号:US-8680297-B2
优先权日:2011-10-06
标题 :Manufacturing process for tiotropium bromide
发明人：SOUKUP MILAN
权利人:SOUKUP MILAN; DRUG PROCESS LICENSING ASSOC LLC
摘要:The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).

专利号:US-2011137047-A1
优先权日:2009-12-07
标题 :Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren
发明人：SOUKUP MILAN
权利人:CarboDesign LLC
摘要:The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III.

专利号:CN-112958151-A
优先权日:2021-02-26
标题 :Mesoporous poly-L-proline catalyst for catalytic synthesis of spiroindolone compounds, preparation method and application thereof