CAS: 524-20-9; (R)-4-((6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-1-yl)Methyl)Phenol
- 英文名称(R)-4-((6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-1-yl)Methyl)Phenol
- 中文名称(-)-亚美罂粟碱
- IUPAC名称(R)-4-((6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenol
- 其它别名R-Armepavine; Phenol, 4-[[(1R)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-2-Methyl-1-Isoquinolinyl]Methyl]-; (-)-Armepavine; (R)-4-((6,7-Dimethoxy-2-Methyl-1,2,3,4-Tetrahydroisoquinolin-1-yl)Methyl)Phenol
- CAS编号524-20-9
- MFCD编号:MFCD02170601
- EINECS号:112-357-0
- FDA UNII编号:RE6Z59021R
- 分子式:C19H23NO3分子量:313.4
- 产品CID: 1513678
- 产品分类有机原料 → 有机杂环化合物 → 异喹啉及其衍生物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号518-94-5 轮环藤碱 | CAS号477-62-3 Is°Chondrodendrine | CAS号1246431-54-8 methyl 2-(3-chl... | CAS号409366-27-4 (3,5-二氯-4-羟基苯基)乙酸甲酯 | CAS号14199-15-6 对羟基苯乙酸甲酯 | CAS号42583-41-5 2-{4-[5-(carbox...合成工艺路线路线简述
- 合成目标产物 Armepavine 主要起始原料 Methyl 4-Hydroxyphenylacetate
- (文献来源)合成步骤主要原料 Methyl 4-Hydroxyphenylacetate
📜轮环藤碱置于氨,Sodium体系中,用 甲苯 作为反应溶剂,化学反应生成 亚美罂粟碱
参考文献:The Biosynthesis Of The Alkaloids Of Cissampelos Pareira Linn
标题:The Biosynthesis Of The Alkaloids Of Cissampelos Pareira Linn
摘要:
DOI:10.1016/s0040-4020(01)81679-3
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907210001-间苯二酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12091696-B2
优先权日:2022-08-10
标 题 :O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof
发明人：CHEN SHA; YU YUETONG
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The present disclosure provides an O-methyltransferase protein with a highly specific catalytic function for multiple benzylisoquinoline alkaloids (BIAs) parent nuclei and an encoding gene and use thereof. Compared with wild-type O-methyltransferase, the O-methyltransferase protein (SEQ ID NO: 2) shows an enhanced enzymatic activity and a wider substrate scope. The O-methyltransferase protein can catalyze O-methylation of backbones from three BIAs, including monobenzylisoquinolines (norcoclaurine, coclaurine, and N-methylcoclaurine), aporphines (asimilobine and N-methylasimilobine), and protoberberines (scoulerine and tetrahydrocolumbamine). Meanwhile, this O-methyltransferase protein is highly regioselective for each backbone. The O-methyltransferase protein catalyzes methylation of the monobenzylisoquinolines at 6-OH and 7-OH, is only active on 6-OH of the backbone of the aporphines, and mainly catalyzes methylation of the protoberberines at 2-OH. Moreover, the O-methyltransferase protein has a stronger catalytic activity and can be used as a biocatalyst for the semi-synthesis of related compounds.
专利号:CN-114891840-A
优先权日:2022-05-23
标 题 :Application of lotus leaf O-methyltransferase and its encoding gene in the synthesis of benzylisoquinoline alkaloids and phenylpropionic acids
专利号:CN-114891840-B
优先权日:2022-05-23
标题:Lotus leaf O-methyltransferase and application of encoding gene thereof in synthesis of benzyl isoquinoline alkaloid and phenylpropionic acid compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Geng P, Luo J, Weng Z, Fan Z, Zhang B, Ma J, Wang X, Zhang M. Determination of armepavine in mouse blood by UPLC-MS/MS and its application to pharmacokinetic study. Biomed Chromatogr. 2018 May
3:e4273. doi: 10.1002/bmc.4273. [Epub ahead of print] pii: E930. doi: 10.3390/molecules21070930.
3: Kumarihamy M, León F, Pettaway S, Wilson L, Lambert JA, Wang M, Hill C, McCurdy CR, ElSohly MA, Cutler SJ, Muhammad I. In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower. J Ethnopharmacol. 2015 Nov 4;174:57-65. doi: 10.1016/j.jep.2015.08.006. Epub 2015 Aug 7.
合成参考文献
参考文献:10.1016/j.lfs.2003.12.017|10.1016/s0024-3205(04)00269-3
摘要:Jow GM, Wu YC, Guh JH, Teng CM. Armepavine oxalate induces cell death on CCRF-CEM leukemia cell line through an apoptotic pathway. Life Sci. 2004 Jun 18;75(5):549–57. doi: 10.1016/j.lfs.2003.12.017.
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