CAS: 39815-78-6; Methyl 3-Oxoheptanoate

相似化合物

22348-97-6 30414-54-1 15889-95-9

上下游产品

methanol α-diazo methyl 3-oxoheptanoate3-Phenyl-2-propyl-cyclohex-2-enone n-hexan-2-one 3-oxoheptanoic acid methyl 3-oxo-6-phenyl-4-propylhexanoate

戊酰氯置于吡啶体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 3-酮庚酸甲酯
参考文献:分离抗生素假吡喃乙并评估c3 / C6烷基类似物的sar.
标题:分离抗生素假吡喃乙并评估c3 / C6烷基类似物的sar.
摘要:天然产物是具有抗菌活性的结构多样的化合物的丰富来源,可用于开发新型有效的抗生素.一类这样的天然产物是假吡喃酮.在这里,我们介绍了从北卡罗莱纳州西部花园土壤中发现的假单胞菌属物种中分离出假吡喃酮b(2),以及对天然产物的c3和c6烷基类似物对革兰氏阳性和革兰氏阴性细菌的抗菌活性的sar评估.我们发现抗菌活性和c3 / C6烷基链长之间存在直接关系.为了抑制革兰氏阳性菌,发现6至7个碳原子之间的烷基链长度最活跃(ic50 = 0.04-3.8µg / Ml),而短链烷基类似物对革兰氏阴性菌的活性中等(ic50 = 223)-304µg / Ml).
DOI:10.1016/j.Bmcl.2017.04.067

专利信息

专利号:US-5194671-A
优先权日:1991-05-23
标题 :Process for the preparation of β-ketocarboxylic acid esters
发明人：MEIER JOSEF
权利人:WACKER CHEMIE GMBH
摘要:The invention relates to a process for the preparation of β-ketocarboxylic acid esters of the general formula ##STR1## in which R 1 is an alkyl radical having 1 to 4 C atoms, R 2 is an alkyl radical or alkenyl radical having 2 to 15 C atoms or a phenyl radical and R 3 is hydrogen or an alkyl or alkenyl radical having 1 to 6 C atoms, characterized in that acetocarboxylic acid esters of the general formula ##STR2## in which R 1 and R 3 are as defined, are reacted with calcium hydroxide or calcium oxide in the presence of an organic solvent and in the absence of water, the calcium chelate complexes formed are acylated with carboxylic acid chloride and the products are then cleaved with aqueous ammonium salt solution to form the β-ketocarboxylic acid esters of formula (I). n The β-ketocarboxylic acid esters readily accessible by the process according to the invention can be used as important intermediates in the synthesis of pharmaceutically active ingredients or plant protection agents.

专利号:US-6642390-B2
优先权日:2001-07-11
标 题:One step synthesis of 1,2,3-triazole carboxylic acids
发明人：KOLB HARTMUTH C; CAVALLARO CULLEN; SHI ZHI-CAI; GONTCHAROV ALEXANDER; WANG ZHI-MIN; RICHARDSON PAUL F; KANAMARLAPUDI RAMANAIAH C
权利人:LEXICON PHARMACEUTICALS INC
摘要:Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a beta-ketoester in the presence of a base.

专利号:US-2003135050-A1
优先权日:2001-07-11
标题 :One step synthesis of 1,2,3-triazole carboxylic acids

专利号:US-5371233-A
优先权日:1991-12-30
标 题:2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates
发明人：DAUMAS MARC; HOORNAERT CHRISTIAN; CHEKROUN ISAAC; BEDOYA-ZURITA MANUEL; RUIZ-MONTES JOSE; ROSSEY GUY; GRECIET HELENE
权利人:SYNTHELABO
摘要:Compounds corresponding to the formula (I) ##STR1## in which X represents dibromomethyl, formyl, (C 1-4 )alkyl, or a group CH(OR 5 ) 2 or CH(OH)OR 5 , wherein the or each R 5 is hydrogen (C 1-3 )alkyl or the two R 5 's in the case of CH(OR 5 ) 2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1-dimethylethyl)dimethylsilyl, (1,1-dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH 2 OR 6 wherein R 6 is methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.

专利号:FR-2973027-A1
优先权日:2011-03-24
标题 :PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES

专利号:FR-2973028-A1
优先权日:2011-03-24
标 题:PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES