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CAS号215500-01-9 pentafluorophen... | CAS号344-07-0 氯五氟苯 | CAS号344-04-7 溴五氟苯 | CAS号392-56-3 六氟苯 | CAS号1582-24-7 2,3,4,5,6-五氟苯基硼酸 | CAS号106-49-0 对甲苯胺 | CAS号104-94-9 对甲氧基苯胺 | CAS号827-15-6 五氟碘苯 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号828-73-9 五氟苯肼 | CAS号105608-98-8 N-(2,3,5,6-tetr... | CAS号1015-53-8 Trimethyl(penta... | CAS号106358-37-6 1,2,3,4,5-penta... | CAS号327-54-8 1,2,4,5-四氟苯 | CAS号551-62-2 1,2,3,4-四氟苯 | CAS号2367-82-0 1,2,3,5-四氟苯 | CAS号563-25-7 二丁基二氟锡 | CAS号1983-10-4 三正丁基氟化锡 | CAS号4084-38-2 2,3,5,6-四氟苯甲醇 | CAS号464-72-2 苯频哪醇

八氟甲苯置于[(η5-Pentamethylcyclopentadienyl)(2,2'-Bipyridine)Rhodium(I)],氢气,三乙胺体系中,用 乙腈 作为反应溶剂,25.0 °C,100.0 Kpa 条件下,反应 24.0H,反应生成 五氟苯
参考文献:Catalytic C-f Bond Hydrogenolysis Of Fluoroaromatics By [(η5-C5Me5)Rhi(2,2'-Bipyridine)]
标题:Catalytic C-f Bond Hydrogenolysis Of Fluoroaromatics By [(η5-C5Me5)Rhi(2,2'-Bipyridine)]
摘要:
DOI:10.1021/om500647H

专利信息

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:WO-9002605-A1
优先权日:1988-09-02
标题:An apparatus and a method for the synthesis of peptides
发明人：MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
权利人:MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
摘要:An apparatus for use in chemical synthesis, especially peptide synthesis, comprises a synthesis chamber unit having a multiplicity of synthesis chambers, each of which has a liquid inlet and a liquid outlet, means for introducing liquid into the individual synthesis chambers and means for simultaneous removal of liquid via the liquid outlets of the synthesis chambers by regulation of the fluid pressure difference between the liquid inlets and the liquid outlets. A method for peptide synthesis using such an apparatus comprises the provision in each of the synthesis chambers of a solid-phase support material having a first, at least N-protected amino acid coupled thereto, after which a liquid deprotection reagent is introduced into the synthesis chambers. Following deprotection, the deprotection reagent is removed, after which a second, at least N-protected amino acid is introduced into each synthesis chamber in order to couple the first and second amino acids. Third, fourth, etc. amino acids may be coupled analogously. Complete removal of the deprotection reagent from the synthesis chambers and the support material can be ensured by incorporating a stable, intensely coloured dye, e.g., azorubin, in the deprotection reagent. The apparatus and the method make possible the parallel synthesis of a large number of peptides, e.g. peptides having overlapping amino acid sequences and constituting part of a longer peptide chain. The apparatus can be adapted to manual, semi-automatic or fully automatic performance of the various steps in the synthesis procedure.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-2005019901-A1
优先权日:2002-01-31
标题 :Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same
发明人：MATVEEVA EVGENIA; VALENCIA RAMONCITO MAGPANTAY; WERNER MARTINA ELISABETH
摘要:Optical bio-disc assays and synthesis of bio-active nanoparticles and nanocapsules for use therewith. Related methods for synthesis of polymeric nanoparticles for use in disc assays include forming reverse micelles having an outer non-polar shell and an inner polar cavity and solubilizing in the reverse micelles a polymerizing mixture including monomers, co-monomers, weakly polar monomers, and/or polymerizable surfactants. This may also include an initiator of polymerization. The methods also include polymerizing the mixture. The invention is also directed to the use of the nanoparticles and nanocapsules in optical bio-disc assays for the detection of analytes including nucleic acid sequences. Related optical assay discs and disc systems are also provided.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:EP-0443532-B1
优先权日:1990-02-20
标题:Temporary minimal protection synthesis of LH-RH analogs
发明人：NESTOR JOHN J JR; MCCLURE NATALIE L
权利人:SYNTEX INC
摘要:A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine, if present, are side chain protected during the synthesis with groups labile to selected alpha -amino or deprotecting agents.