CAS: 360-64-5; 2-(Trifluoromethyl)Benzamide

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CAS号312-94-7 2-三氟甲基苯甲酰氯 | CAS号3038-48-0 2-三氟甲基苯乙酸 | CAS号447-60-9 邻三氟甲基苯腈 | CAS号3930-83-4 2-碘苯甲酰胺 | CAS号77152-08-0 copper(1+),trif... | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号344-96-7 2-(三氟甲基)苯甲酸甲酯 | CAS号529-19-1 邻甲基苯腈 | CAS号2635-68-9 2-(三氯甲基)苯甲腈 | CAS号66332-96-5 氟酰胺 | CAS号447-60-9 邻三氟甲基苯腈 | CAS号3048-01-9 2-(三氟甲基)苄胺 | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号2944-97-0 [2-(trifluorome... | CAS号88-17-5 2-氨基三氟甲苯

2-硝基-Alpha,Alpha,Alpha-三氟甲苯置于四丁基氟化铵,双氧水,Sodium Hydroxide体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 12.0H,反应生成2-(三氟甲基)苯甲酰胺
参考文献:一种邻三氟甲基苯甲酰胺的制备方法
标题:一种邻三氟甲基苯甲酰胺的制备方法
摘要:本发明公开了一种邻三氟甲基苯甲酰胺的制备方法.该制备方法包括如下步骤:(1)在有机溶剂中,将邻硝基三氟甲苯和氟化盐进行如下所示的脱硝氟代反应,得到邻氟三氟甲苯;(2)在有机溶剂中,将邻氟三氟甲苯和氰基化试剂进行如下所示的脱氟氰代反应,得到邻三氟甲基苯腈;(3)在碱存在下,将邻三氟甲基苯腈,过氧化氢进行如下所示的水解反应.该制备方法后处理简单,产物纯度高,杂质少,收率高.

专利信息

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:WO-2012014114-A1
优先权日:2010-07-30
标 题:Matrix metalloproteinase inhibitors
发明人：KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.

专利号:WO-2012094334-A1
优先权日:2011-01-04
标题 :One-step 18f labeling of biological substrates and uses of 18f labeled biological substrates
发明人：CHEN XIAOYUAN; JACOBSON WEISS ORIT
权利人:US HEALTH; CHEN XIAOYUAN; JACOBSON WEISS ORIT
摘要:Disclosed is a rapid one-step 18 F radiolabeling method for biological substrates that contain a specific arene group activated for nucleophilic aromatic substitution with 18 F. The method involves reacting a biological substrate having at least one 4-nitro-3-trifluorobenzamide moiety covalently bonded thereto with a 18 F anion in the presence of a cryptand. The method of the present invention has one or more advantages: significantly shortens reaction and overall synthesis time; requires low amount of precursor; and provides acceptable yields of high specific activity product. Also disclosed are methods of identifying a cell or population of cells expressing a protein or peptide of interest and methods for diagnosing a disease in a subject. Further disclosed are 18 F labeled compounds of formula (I): wherein X, n, R 1 , R 2 , and R 3 are as described herein.