CAS: 20972-36-5; (2E)-4-(4-Methylphenyl)-4-Oxobut-2-Enoic Acid

该化合物是具有独特结构特征的有机化合物,含有丙烯酸碱,是丙基-二-蛋酸的衍生物,以及4-甲基苯并基组,有助于其芳香特性.该化合物一般在室温中呈现固态,并因其在包括制药和材料科学在内的各个领域的潜在应用而闻名.其结构中的碳箱酸功能组和碳碳-碳双重结合都允许聚合体和其他化学反应中发生再活动.此外,芳香环上的甲基组可以影响其溶性和再活动,使其成为合成有机化学的一个利益主体.其变性意义重大,因为它影响化合物的物理特性和再活动,与其精密对应.

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上下游产品

maleic anhydride toluene (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide p-tolyl-2,2'-pyrrole-2,5-diyl-di-butyric acid4,4'-dioxo-4,4'-di-p-tolyl-2,2'-pyrrole-2,5-diyl-di-butyric acid p-tolyl-butyric acid2-(4-methyl-phenacyl)-4-oxo-4-p-tolyl-butyric acid para-methylacetophenone Glyoxilic acid

合成工艺路线路线简述

    📜3-Dimethylamino-1-(4-Methyl-Phenyl)-2-Propen-1-One置于盐酸,水,Sodium Carbonate体系中,用 乙腈 用作溶剂,化学反应 15.0H,反应生成Trans-3-(4-甲基苯甲酰)丙烯酸
    参考文献:Brcf2Co2Et 碱促进烯胺酮环化二氟亚甲基化反应生成2,2-二氟代 2,3-二氢呋喃
    标题:Brcf2Co2Et 碱促进烯胺酮环化二氟亚甲基化反应生成2,2-二氟代 2,3-二氢呋喃
    摘要:通过烯胺酮和brcf 2 Co 2 Et 与na 2 Co 3促进的[4 + 1] 环化,建立了一种合成2,2-二氟代2,3-二氢呋喃的实用方法.该新方案不使用任何过渡金属试剂,并通过 C=c 双键的部分裂解实现环状二氟甲基化.此外,在一锅中用盐酸进一步处理会通过形式烯胺酮 C-N 羧化反应生成β-酮烯酸(4-氧代-2-丁烯酸).
    Doi:10.1021/acs.Orglett.2C00671

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    专利信息


    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人：ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:US-9499465-B2
    优先权日:2013-03-15
    标题 :Synthesis of biobased and substituted terephthalic acids and isophthalic acids
    发明人：FROST JOHN W
    权利人:UNIV MICHIGAN STATE
    摘要:Methods for producing bio-terephthalic acid and bio-isophthalic acid are provided. The methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and iso-phthalic acid from the bio-para-toluic acid and bio-meta-toluic acid.

    专利号:US-2016031787-A1
    优先权日:2013-03-15
    标 题 :Synthesis of biobased and substituted terephthalic acids and isophthalic acids

    专利号:WO-2014144843-A1
    优先权日:2013-03-15
    标 题 :Synthesis of biobased terephthalic acids and isophthalic acids

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    主要参考文献

    参考标题:Microwave-Assisted Synthesis Of 4-Oxo-2-Butenoic Acids By Aldol-Condensation Of Glyoxylic Acid
    作者:Mélanie Uguen,Conghao Gai,Lukas J. Sprenger,Hang Liu,Andrew G. Leach,Michael J. Waring
    摘要:4-Oxobutenoic Acids Are Useful As Biologically Active Species And As Versatile Intermediates For Further Derivatisation. Currently, Routes To Their Synthesis Can Be Problematic And Lack Generality. Reaction Conditions For The Synthesis Of 4-Oxo-2-Butenoic Acid By Microwave-Assisted Aldol-Condensation Between Methyl Ketone Derivatives And Glyoxylic Acid Have Been Developed. They Provide The Desired

    合成参考文献


    摘要:Elliott, M. C.; Jones, D. H., Science of Synthesis: Multicomponent Reactions, (2013) 2, 246.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 173.
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