CAS: 1983-26-2; (Chloromethyl)Phosphonic Dichloride

上下游产品

formaldehyd dichloromethane dichloro(chloromethyl)phosphine hydroxymethylphosphonic aciddiisopropyl α-chloromethylphosphonate chloromethyl-phosphonic acid dibutyl ester dimethyl α-chloromethylphosphonate Chlormethyl-phosphonsaeure-dipropylester

📜羟甲基膦酸置于吡啶,氯化亚砜体系中,化学反应生成氯甲基膦酸二氯化物
参考文献:有机磷化合物:Ii:二氯化氯甲烷的制备
标题:有机磷化合物:Ii:二氯化氯甲烷的制备
摘要:羟基甲烷膦酸是通过在大气压下用三氯化磷处理多聚甲醛并随后水解所得复合物来制备的.氯甲烷磷...
Doi:10.1139/v53-128

专利信息

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-6972320-B2
优先权日:2000-05-12
标题 :Ligation method and reagents to form an amide bond
发明人：RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosphinothioester which reacts with an azide resulting in amide formation. The invention provides phosphinothiol reagents which convert activated carboxylic acid derivatives to phosphinothioesters which then react with azides to form an amide bond. The methods and reagents of the invention can be used for stepwise synthesis of peptides on solid supports or for the ligation to two or more amino acids, two or more peptide or two or more protein fragments.

专利号:EP-0533833-B1
优先权日:1990-06-13
标题:Phosphorous produgs
发明人：GLAZIER ARNOLD
权利人:GLAZIER ARNOLD
摘要:The composition and methods of synthesis of several prodrugs are described. These methods may be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and through biological membranes. Prodrugs for a variety of antiviral and anti-leukemic agents are described. A class of prodrugs which undergo degradation by an elimination reaction to form a carbon-carbon double bond is described. This elimination reaction is triggered by esterase.

专利号:DE-1924135-A1
优先权日:1968-05-15
标 题:Synthesis of epoxyphosphonates

专利号:EP-0270885-A1
优先权日:1986-11-18
标 题 :Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids