CAS: 151606-29-0; Zinquin
该化合物是一个化学化合物,主要用作探测生物系统中锌离子的荧光探测器,其特点是它能够有选择地捆绑锌,导致荧光度的大幅提高,从而能够对细胞和组织中的锌含量进行敏感的成像和量化.该化合物一般表现出锌离子的高度亲近性,使其成为生物化学研究的有效工具,特别是在有关锌在细胞过程和信号路径中的作用的研究中.Zinquin Ethyl Ester由于其细胞渗透性,常常用于活细胞成像,使研究人员能够实时监测锌的动态.此外,其荧光性能还可能受到诸如pH等环境因素的影响,以及其它金属离子的存在,这对于准确解释实验结果至关重要.总的来说,Zinquin Ethy Ester在生物化学和分子生物学领域充当有价值的试剂,用于研究各种生物环境中的锌相关功能.
- 英文名称Zinquin
- 中文名称2-[2-甲基-8-[(4-甲基苯基)磺酰基氨基]喹啉-6-基]氧基乙酸
- IUPAC名称2-((2-methyl-8-((4-methylphenyl)sulfonamido)quinolin-6-yl)oxy)acetic acid
- 其它别名Ethyl [2-Methyl-8-[[(4-Methylphenyl)Sulfonyl]Amino]-6-Quinolinyl]Oxy Acetate; Ethyl(2-Methyl-8-P-Toluenesulfonamido-6-Quinolyloxy)Acetate; Zinquin-E; Zinquin Ethyl Ester; 2-Methyl-8-[(4-Methylphenyl)Sulfonylamino]-6-(Ethyloxycarbonylmethyloxy)Quinoline; 2-Methyl-8-(4-Methylphenylsulfonylamino)Quinolinyl]Oxyacetic Acid Ethyl Ester; Ethyl[[2-Mthyl-8-[[(4Methylphenyl)Sulfonyl]Amino]-6-Quinolinyl]Oxy]Acetate; Ethyl[[2-Methyl-8-[[(4-Methylphenyl)Sulfonyl]Amino]-6-Quinolinyl]Oxy]Acetate (Zinquin Ethyl Ester)
- CAS编号151606-29-0
- MFCD编号:MFCD00797629
- FDA UNII编号:Z74RD6XLAC
- 分子式:C19H18N2O5S分子量:386.43
- 产品CID: 740660
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2905310000-1,2-乙二醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-2009325858-A1
优先权日:2003-03-21
标 题:Reduction of Zinc-Induced Neurotoxic Injury By Blockade of Nitric Oxide Synthesis
发明人：FREDERICKSON CHRISTOPHER J
权利人:ANDRO DIAGNOSTICS INC
摘要:The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.
专利号:US-2004235751-A1
优先权日:2003-03-21
标题 :Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis
专利号:WO-2004084827-A2
优先权日:2003-03-21
标 题:Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Colvin RA, Laskowski M, Fontaine CP. Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment. Brain Res. 2006 Apr 26;1085(1):1-10. doi: 10.1016/j.brainres.2006.02.043. Epub 2006 Apr 11. 303 ( Pt 3)(Pt 3):781-6. doi: 10.1042/bj3030781.
3: Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR. Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments. Biophys J. 2001 Mar;80(3):1538-46. doi: 10.1016/S0006-3495(01)76126-7.
4: Nowakowski AB, Petering DH. Reactions of the fluorescent sensor, Zinquin, with the zinc-proteome: adduct formation and ligand substitution. Inorg Chem. 2011 Oct 17;50(20):10124-33. doi: 10.1021/ic201076w. Epub 2011 Sep 9.
合成参考文献
参考文献:10.4161/cbt.12.4.16356
摘要:Costello LC, Levy BA, Desouki MM, Zou J, Bagasra O, Johnson LA, Hanna N, Franklin RB. Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma. Cancer Biology & Therapy. 2011 Aug 15;12(4):297–303. doi: 10.4161/cbt.12.4.16356.
参考文献:10.1385/bter:96:1-3:133
摘要:Jansen S, Arning J, Beyersmann D. Effects of the Ca ionophore A23187 on zinc-induced apoptosis in C6 glioma cells. Biological Trace Element Research. 2003 Dec;96(1-3):133–42. doi: 10.1385/bter:96:1-3:133.
参考文献:10.1016/j.ab.2004.05.003
摘要:Jansen S, Arning J, Dülcks T, Beyersmann D. S-Nitroso compounds interfere with zinc probing by Zinquin. Anal Biochem. 2004 Sep 01;332(1):145–52. doi: 10.1016/j.ab.2004.05.003.
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