CAS: 13349-91-2; 1-(2,2,2-Trifluoroethyl)Piperazine Dihydrochloride

相似化合物

13349-90-1 245487-45-0 692058-21-2

上下游产品

CAS号692058-21-2 1-B°C-4-(2,2,2-... | CAS号13349-90-1 1-(2,2,2-三氟乙基)哌嗪

📜盐酸,4-(2,2,2-三氟乙基)哌嗪-1-羧酸叔丁酯 以 1,4-二氧六环 用作溶剂,化学反应 3.0H,以to Yield 1-(2,2,2-Trifluoroethyl)Piperazine Dihydrochloride (0.631 G,95%) As A White Solid的收率获得1-(2,2,2-三氟乙基)哌嗪二盐酸盐
参考文献:Chiral Cis-Imidazolines
标题:Chiral Cis-Imidazolines
摘要:"and The Pharmaceutically Acceptable Salts And Esters Thereof,Wherein X1,X2,X3,Y1,Y2And R Are Described Herein Inhibit The Interaction Of Mdm2 Protein With A P53-Like Peptide And Hence Have Anti Proliferative Activity." 翻译成中文为:"其中x1,X2,X3,Y1,Y2和r所描述的药物可接受的盐和酯类物质,能够抑制mdm2蛋白与p53样肽的相互作用,从而具有抗增殖活性."

专利信息

专利号:US-11325903-B2
优先权日:2016-11-30
标 题:Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
发明人：SIDDIQUI M ARSHAD; CIBLAT STEPHANE; DERY MARTIN; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; BRUNEAU-LATOUR NICOLAS; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW J; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R 1 , L 1 , L 2 , Q, L 3 , R 3 , L 4 , R 4 , L 5 , and R 5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.