专利号:US-2023002805-A1 优先权日:2021-06-25 标 题 :Use of organic cationic compounds to accelerate nucleic acid hybridization, synthesis, and amplification 发明人:RABBANI ELAZAR; COLEMAN JACK 权利人:ENZO BIOCHEM INC 摘要:The invention provides methods for accelerated synthesis of nucleic acids, and related compositions which involve the use of organic amines in the nucleic acid synthesis reaction mixture. The invention also provides methods for reducing processing steps associated with nucleic acid synthesis. The invention further provides methods for screening compounds that have positive benefits on the synthesis of nucleic acids.
专利号:US-11066426-B2 优先权日:2018-03-05 标题 :Methods of making porous molecular structures 发明人:JOSHI JAYRAJ NAYAN; MORAN COLTON MICHAEL; WALTON KRISTA S 权利人:GEORGIA TECH RES INST 摘要:Disclosed herein is a method of making a porous molecular structure from a solution comprising an insoluble metal containing material and a ligand-providing material. In some embodiments, the porous molecular structure can be a Metal-Organic Framework (MOF). Ionic metal salts are the most common type of metal source for MOF production, but dissolution of metal salts complicates solvent recycling and creates corrosion and oxidation issues through evolved nitrate and chloride anions. Elucidating information that leads toward more efficient production of these versatile nanomaterials, while extending the knowledge base of how MOFs form during reaction, is critical to advancing MOF materials into large-scale use. Disclosed herein are improved methods for controlled synthesis of porous molecular structures such as MOFs comprising a solution-based synthesis with insoluble metallic precursor.
专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
专利号:US-8084495-B2 优先权日:2004-02-03 标题 :Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation for PPR-gamma receptors 发明人:HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN 权利人:HANCKE OROZCO JUAN LUIS; BURGOS AGUILERA RAFAEL AGUSTIN; HERBAL POWERS CORP 摘要:The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone, chemically diagrammed as n ninhibits the synthesis of pro-inflammatory cytokines, activates the PPAR-gamma receptor and diminishes nuclear factor kappa B.n n The compound is useful to treat auto-immune diseases, for organ and tissue transplantation, and to treat immunodeficiency (e.g., AIDS).
专利号:US-11959137-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
专利号:US-2024376536-A1 优先权日:2015-09-28 标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis
参考文献:10.1186/1471-2199-12-29 摘要:Wen X, Chao C, Ives K, Hellmich MR. Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells. BMC Molecular and Cell Biology. 2011 Jul 11;12(1):29. doi: 10.1186/1471-2199-12-29. 参考文献:10.1002/cne.20807 摘要:Hamasaka Y, Nässel DR. Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila. J of Comparative Neurology. 2005 Nov 30;494(2):314–30. doi: 10.1002/cne.20807. 参考文献:10.1186/ar3400 摘要:Chang BY, Huang MM, Francesco M, Chen J, Sokolove J, Magadala P, Robinson WH, Buggy JJ. The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther. 2011 Jul 13;13(4):R115. 参考文献:10.1186/1471-2407-11-296 摘要:Serrano FA, Matsuo AL, Monteforte PT, Bechara A, Smaili SS, Santana DP, Rodrigues T, Pereira FV, Silva LS, Machado J, Santos EL, Pesquero JB, Martins RM, Travassos LR, Caires AC, Rodrigues EG. A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells. BMC Cancer. 2011 Jul 14;11():296. 参考文献:10.1371/journal.pone.0019186 摘要:Mak MC, Lam KM, Chan PK, Lau YB, Tang WH, Yeung PKK, Ko BCB, Chung SMS, Chung SK. Embryonic Lethality in Mice Lacking the Nuclear Factor of Activated T Cells 5 Protein Due to Impaired Cardiac Development and Function. PLoS ONE. 2011 Jul 12;6(7):e19186. doi: 10.1371/journal.pone.0019186.