CAS: 942437-37-8; 4-Amino-8-(2-Fluoro-6-Methoxyphenyl)-N-Propylcinnoline-3-Carboxamide

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4-氨基-8-溴-N-丙基氮杂嗪-3-胺 4-Amino-8-Bromo-N-Propylcinnoline-3-Carboxamide 107346-32-7

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  • 107346-32-7 + 78495-63-3 = 942437-37-8
    反应条件:1.1 Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: Isopropanol,Tetrahydrofuran; 15 Min,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; 90 Min,65 °C
    标题:Preparation Of Crystalline Forms Of 4-Amino-8-(2-Fluoro-6-Methoxyphenyl)-N-Propylcinnoline-3-Carboxamide Hydrogen Sulfate For Treatment Of Anxiety Disorders
    参考文献:World Intellectual Property Organization]

    107346-32-7 + 78495-63-3 = 942437-37-8
    反应条件:1.1 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: Isopropanol,Tetrahydrofuran; 15 Min,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; 80 °C; 90 Min,65 °C; 65 °C -> Rt
    标题:Preparation Of Aminocinnolinecarboxamides For The Treatment Of Schizophrenia
    参考文献:World Intellectual Property Organization]

    107346-32-7 + 78495-63-3 = 942437-37-8
    反应条件:1.1 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: Isopropanol,Tetrahydrofuran; 15 Min,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Rt; 90 Min,65 °C; 65 °C -> Rt
    标题:Preparation Of Novel Cinnoline Compounds For Treating Anxiety,Depression And Cognition Disorders
    参考文献:United States]

    107346-32-7 + 78495-63-3 = 942437-37-8
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Ethanol,1,2-Dimethoxyethane,Water; 90 °C
    标题:Development And Sar Of Functionally Selective Allosteric Modulators Of Gabaa Receptors
    作者:Alhambra,Cristobal; Becker,Chris; Blake,Timothy; Chang,Amy; Damewood,James R. Jr.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(9) 页码:2927-2938
📜(E)-N-Propyl-2-Cyano-2-[(2-Bromophenyl)Hydrazono]Acetamide置于aluminum (Iii) Chloride,四(三苯基膦)钯,Potassium Carbonate体系中,用 乙二醇二甲醚,乙醇,水,甲苯 作为反应溶剂,化学反应生成 化合物azd-7325
参考文献:Development And Sar Of Functionally Selective Allosteric Modulators Of Gabaa Receptors
标题:Development And Sar Of Functionally Selective Allosteric Modulators Of Gabaa Receptors
摘要:Positive Modulators At The Benzodiazepine Site Of Alpha 2-And Alpha 3-Containing Gaba(A) Receptors Are Believed To Be Anxiolytic. Through Oocyte Voltage Clamp Studies,We Have Discovered Two Series Of Compounds That Are Positive Modulators At Alpha 2-/alpha 3-Containing Gaba(A) Receptors And That Show No Functional Activity At Alpha 1-Containing Gabaa Receptors. We Report Studies To Improve This Functional Selectivity And Ultimately Deliver Clinical Candidates. The Functional Sar Of Cinnolines And Quinolines That Are Positive Allosteric Modulators Of The Alpha 2-And Alpha 3-Containing Gaba(A) Receptors,While Simultaneously Neutral Antagonists At Alpha 1-Containing Gabaa Receptors,Is Described. Such Functionally Selective Modulators Of Gaba(A) Receptors Are Expected To Be Useful In The Treatment Of Anxiety And Other Psychiatric Illnesses. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2011.03.035

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主要参考文献


1: Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL. The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54. doi: 10.1002/cpdd.134. Epub 2014 Aug 28. doi: 10.1111/bcp.12413.
3: Zhou D, Lu Z, Sunzel M, Xu H, Al-Huniti N. Population pharmacokinetic modelling to assess clinical drug-drug interaction between AZD7325 and midazolam. J Clin Pharm Ther. 2014 Aug;39(4):404-10. doi: 10.1111/jcpt.12152. Epub 2014 Apr 1. doi: 10.1111/j.1365-2125.2011.04155.x.

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摘要:Li, J. J., Science of Synthesis: Knowledge Updates, (2025) 2.
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