CAS: 940284-18-4; 2-(Methylthio)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidine

英文名称2-(Methylthio)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidine
中文名称2-甲基硫代嘧啶-5-硼酸频那酯
IUPAC名称2-(methylthio)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
其它别名2-(甲基硫代)嘧啶-5-硼酸频那醇酯; 3-Hydroxy-2,3-Dimethylbutan-2-Yl Hydrogen (2-(Methylthio)Pyrimidin-5-yl)Boronate
CAS编号940284-18-4
MFCD编号:MFCD07781247
EINECS号:182-971-1
分子式:C11H17BN2O2S分子量:252.15
产品CID: 1985850
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: AFKIHRZPPIRQCI-UHFFFAOYSA-N
InChI=1S/C11H17BN2O2S/c1-10(2)11(3,4)16-12(15-10)8-6-13-9(17-5)14-7-8/h6-7H,1-5H3
计算化学: 氢键受体数5.0氢键供体数*可旋转键数2.0

相似化合物

348098-29-3 321724-19-0 1052686-67-5

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
危险品标志Xi
WGK Germany3

欧盟法规

C&L通报

上下游产品

5-bromo-2-methylthiopyrimidine bis(pinacol)diborane 2-methylthio-5-hydroxypyrimidine 2-(3,4-dimethoxy-phenyl)-5-(2-methylsulfanyl-pyrimidin-5-yl)-imidazo[2,1-b][1,3,4]thiadiazole 2-{2-fluoro-4-[2-(methylsulfanyl)pyrimidin-5-yl]phenyl}-6-(trifluoromethyl)-1H-benzimidazole tert-butyl [trans-4-({3-[2-(methylsulfanyl)pyrimidin-5-yl]imidazo-[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

合成工艺路线路线简述

73183-34-3 + 14001-67-3 = 940284-18-4
反应条件:1.1 Catalysts: Palladium Diacetate,[1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 12 H,80 °C
标题:Preparation Of Substituted Phenylpyridinylmethylpiperidines,Phenylpyridinylmethylpiperazines And Their Analogs As Furin Inhibitors
参考文献:World Intellectual Property Organization]

73183-34-3 + 14001-67-3 = 940284-18-4
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: Dimethyl Sulfoxide; 6 H,100 °C
标题:Preparation Of Novel Benzimidazole Derivatives As Dgat-1 Inhibitors
参考文献:World Intellectual Property Organization]

73183-34-3 + 14001-67-3 = 940284-18-4
反应条件:1.1 Catalysts: Potassium Acetate,Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: Dimethyl Sulfoxide; 6 H,100 °C; 100 °C -> Rt
标题:Preparation Of Imidazopyridinylphenylpyridinylpiperidinylacetic Acid Derivatives And Analogs For Use As Dgat1 Inhibitors
参考文献:World Intellectual Property Organization]

73183-34-3 + 14001-67-3 = 940284-18-4
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Palladium Diacetate Solvents: Dimethylformamide; Rt; Overnight,85 °C; 85 °C -> Rt
标题:Preparation Of Pyridone And Pyridazone Analogues As Gpr119 Modulators
参考文献:World Intellectual Property Organization]

73183-34-3 + 14001-67-3 = 940284-18-4
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: Dimethyl Sulfoxide; 4 H,80 °C; Overnight,100 °C
标题:Preparation Of Pyrazolopyrimidine Derivatives Or Analogs Thereof As Ccr4 Function Modulators
参考文献:Japan

📜5-溴-2-甲巯基嘧啶,联硼酸频那醇酯置于palladium Diacetate Potassium Acetate体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2-甲基硫代嘧啶-5-硼酸频那酯
参考文献: Pyridone And Pyridazone Analogues As Gpr119 Modulators[fr] Analogues De Pyridone Et De Pyridazone Comme Modulateurs De Gpr119
标题: Pyridone And Pyridazone Analogues As Gpr119 Modulators[fr] Analogues De Pyridone Et De Pyridazone Comme Modulateurs De Gpr119
摘要:提供结构式(i)或其对映体,顺反异构体或药用可接受盐的新化合物,其中z,R1,R2,R21,T1,T2,T3和t4在此定义,这些化合物是gpr119 G蛋白偶联受体调节剂. Gpr119 G蛋白偶联受体调节剂在治疗,预防或减缓需要gpr119 G蛋白偶联受体调节剂治疗的疾病方面是有用的.因此,该公开还涉及包含这些新化合物的组合物和使用任何这些新化合物或包含任何这种新化合物的组合物治疗与gpr119 G蛋白偶联受体活性相关的疾病或症状的方法.