CAS: 92992-85-3; 2-Bromo-3,5-Dimethylpyridine

该化合物是一种有机化合物,其特征为:环,是含有一个氮原子的由六人组成的芳香热循环,在环的3和5个位置上存在两个甲基组,造成其疏水性并影响其再活动.2位置上的溴原子具有卤素功能,使其成为各种化学合成的有用中间体,特别是在制药和农用化学品制作过程中.这种化合物一般表现为无色的黄色液体或固体,视其形态和纯度而定.它溶于有机溶剂中,但因其非极性甲基组而水溶性有限.该化合物的再活动受溴原子的电阻作用影响,可参与核糖替代反应.在处理该化合物时,应注意安全防范,因为如果吸入或浸入,可能会对健康造成危害,因此应保持适当的储存条件,以确保稳定性.

英文名称2-Bromo-3,5-Dimethylpyridine
中文名称2-溴-3,5-二甲基吡啶
IUPAC名称2-bromo-3,5-dimethylpyridine
其它别名2-Bromo-3,5-Dimethylpyridine; 3,5-Dimethyl-2-Bromopyridine; 2-Bromo-3,5-Lutidine; Pyridine, 2-Bromo-3,5-Dimethyl-; Jhggkvfegbewqr-Uhfffaoysa-N
CAS编号92992-85-3
MFCD编号:MFCD00234308
EINECS号:800-193-9
分子式:C7H8BrN
分子量:186.05
产品CID: 1968798
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: JHGGKVFEGBEWQR-UHFFFAOYSA-N
InChI=1S/C7H8BrN/c1-5-3-6(2)7(8)9-4-5/h3-4H,1-2H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

117846-58-9 3430-17-9 66533-31-1

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
严重眼损伤类别1
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264-P270-P280-P330-P501
危险等级8
UN编号1760.0
包装等级Ⅲ

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号591-22-0 3,5-二甲基吡啶 | CAS号86609-11-2 3,5-dimethyl-1-... | CAS号41995-30-6 2-氨基-3,5-二甲基吡啶 | CAS号1373615-35-0 1-[4-(5'-氯-3,5-...

合成工艺路线路线简述

591-22-0 = 92992-85-3
反应条件:1.1 Reagents: Diisopropylamine,Butyllithium Solvents: Diethyl Ether; -10 °C1.2 Reagents: Boron Trifluoride Etherate Solvents: Diethyl Ether; 10 Min,0 °C1.3 Solvents: Diethyl Ether; 10 Min,-78 °C; 15 Min,-78 °C1.4 Reagents: Bromine; -78 °C; -78 °C -> Rt1.5 Reagents: Water Solvents: Water
标题:Complex-Induced Proximity Effect In The Regioselective Lithiation Of Pyridine Derivatives
作者:Dhau,Jaspreet S.; Singh,Amritpal; Kasetti,Yoganjaneyulu; Bharatam,P. V.
参考文献:European Journal Of Organic Chemistry 日期:2012 卷标:2012(9) 页码:1746-1752]

591-22-0 = 92992-85-3
反应条件:1.1 Reagents: 2-(Dimethylamino)Ethanol,Butyllithium Solvents: Hexane1.2 Solvents: Hexane
标题:Ring Selective Lithiation Of 3,5-Lutidine. A New Route To Heterocyclic Building Blocks
作者:Gros,Philippe; Viney,Cedric; Fort,Yves
参考文献:Synlett 日期:2002 卷标:(4) 页码:628-630]

41995-30-6 = 92992-85-3
反应条件:1.1 Reagents: Sodium Nitrite,Bromine,Hydrogen Bromide Solvents: Water
标题:Novel Palladium Catalzed Phosphination Using Triarylphosphines: Synthesis Of Atropisometric P,N Ligands And Their Application In Asymmetric Hydroboration
作者:Kwong,Fuk Yee
参考文献:2000]

591-22-0 = 92992-85-3
反应条件:1.1 Reagents: 2-(Dimethylamino)Ethanol,Butyllithium Solvents: Hexane; 15 Min,0 °C; 0 °C; 1 H,0 °C1.2 Reagents: Carbon Tetrabromide Solvents: Hexane; -78 °C; 0.5 H,-78 °C
标题:Preparation Of Imidazopyridylmethyl Substituted Piperidine Derivatives Useful As Therapeutic Orexin Antagonists
参考文献:World Intellectual Property Organization]

591-22-0 = 92992-85-3 + 117846-58-9
反应条件:1.1 Reagents: Sulfur Trioxide,Sulfuric Acid,Bromine
标题:The Bromination Of Lutidines
作者:Dunn,Allan D.; Guillermic,Sandrine
参考文献:Zeitschrift Fuer Chemie 日期:1988 卷标:28(2) 页码:59-60

3,5-二甲基吡啶置于正丁基锂,Lithium-2-(Dimethylamino)Ethanolat,四溴化碳体系中,用正己烷作为反应溶剂,化学反应 2.0H,以88%的收率获得产物2-溴-3,5-二甲基吡啶
参考文献:3,5-二甲基吡啶的环选择性锂化.通往杂环积木的新途径.
标题:3,5-二甲基吡啶的环选择性锂化.通往杂环积木的新途径.
摘要:3,5-二甲基吡啶的第一次直接环锂化是通过 Buli-Lidmae 试剂进行的.已经进行了成功的连续金属化和亲电缩合,从而获得了新的有用的多取代吡啶.
DOI:10.1055/s-2002-22702

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

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