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专利信息
专利号:US-9862687-B2
优先权日:2013-11-15
标题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
发明人:WARE JR ROY WENDELL; DOWNEY AARON LEIGH
权利人:CHIMERIX INC; CHIMERIX INC
摘要:The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
专利号:US-9303051-B2
优先权日:2010-08-31
标 题 :Phosphonate ester derivatives and methods of synthesis thereof
发明人:WARE ROY W; ALMOND MERRICK R; LAMPERT BERNHARD M
权利人:CHIMERIX INC; CHIMERIX INC
摘要:The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
专利号:US-9744154-B2
优先权日:2010-03-23
标题:Polymorphic forms of ST-246 and methods of preparation
发明人:TYAVANAGIMATT SHANTHAKUMAR R; ANDERSON MELIALANI A C L S; WEIMERS WILLIAM C; NELSON DYLAN; BOLKEN TOVE′ C; HRUBY DENNIS E; O'NEILL MICHAEL H; SWEETAPPLE GARY; MCCLOUGHAN KELLEY A
权利人:SIGA TECH INC
摘要:Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
专利号:US-2019016687-A1
优先权日:2013-11-15
标 题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
专利号:US-11912667-B2
优先权日:2013-11-15
标 题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
专利号:US-8962829-B1
优先权日:2013-11-15
标 题 :Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof