CAS: 884495-39-0; 5-Bromo-2-Methoxypyridin-3-Amine

• 英文名称5-Bromo-2-Methoxypyridin-3-Amine
• 中文名称3-氨基-5-溴-2-甲氧基吡啶
• IUPAC名称5-bromo-2-methoxypyridin-3-amine
• 其它别名3-氨基-5-溴-2-甲氧基吡啶 2-甲氧基-3-氨基-5-溴吡啶; 5-Bromo-2-Methoxy-Pyridin-3-Amine
• CAS编号884495-39-0
• MFCD编号:MFCD07368887
• EINECS号:804-695-9
• 分子式:C6H7BrN2O
• 分子量:203.04
• 产品CID: 1895132
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: HJOOFLFWIISCAI-UHFFFAOYSA-N
• InChI=1S/C6H7BrN2O/c1-10-6-5(8)2-4(7)3-9-6/h2-3H,8H2,1H3…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

物理性质

• 熔点53-55°C
• 沸点284.5±35.0 °C at 760 mmHg
• 闪点125.9±25.9 °C
• 密度1.6±0.1 g/cm3
• pKa:1.98±0.20(预测)
• PSA:48.14
• LogP:1.4349
• 折射率1.602
• 蒸汽压0.0±0.6 mmHg at 25°C
• 溶解性Slightly Soluble In Water.
• 外观形态浅黄色到黄色 粉末
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用该化合物用于中间药剂.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  皮肤致敏 类别1
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H317 |可能引起皮肤过敏反应.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级8
• UN编号3259.0
• 危险品标志Xn
• 包装等级Ⅲ
• 安全声明26-36/37/39
• 危险类别码22-37/38-41-43
• WGK Germany3.0

欧盟法规

上下游产品

合成工艺路线路线简述

• 67443-38-3 = 884495-39-0
  反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol; 0 °C -> Rt2.1 Reagents: Iron,Ammonium Chloride Solvents: Water; 90 °C
  标题:Discovery Of Benzenesulfonamide Derivatives As Potent Pi3K/mtor Dual Inhibitors With In Vivo Efficacies Against Hepatocellular Carcinoma
  作者:Chen,Ying; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2016 卷标:24(5) 页码:957-966]
  
  15862-34-7 = 884495-39-0
  反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 2 H,Reflux2.1 Solvents: Methanol; Overnight,Rt3.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; Reflux
  标题:Alkylsulfonamide-Containing Quinazoline Derivatives As Potent And Orally Bioavailable Pi3Ks Inhibitors
  作者:Hei,Yuan-Yuan; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(20)]
  
  67443-38-3 = 884495-39-0
  反应条件:1.1 Solvents: Methanol; Overnight,Rt2.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; Reflux
  标题:Alkylsulfonamide-Containing Quinazoline Derivatives As Potent And Orally Bioavailable Pi3Ks Inhibitors
  作者:Hei,Yuan-Yuan; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(20)]
  
  15862-34-7 = 884495-39-0
  反应条件:1.1 Reagents: Silver Carbonate Solvents: Chloroform; 48 H,Rt2.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; 4 H,Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water
  标题:[11C]Gsk2126458 And [18F]Gsk2126458,The First Radiosynthesis Of New Potential Pet Agents For Imaging Of Pi3K And Mtor In Cancers
  作者:Wang,Min; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(4) 页码:1569-1574]
  
  15862-34-7 = 884495-39-0
  反应条件:1.1 Reagents: Phosphorus Oxychloride Catalysts: Dimethylformamide; 3 H,Reflux2.1 Reagents: Sodium Methoxide; 0 °C; 0 °C -> Rt; Overnight,Rt3.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; 4 H,Reflux3.2 Reagents: Sodium Hydroxide Solvents: Water
  标题:[11C]Gsk2126458 And [18F]Gsk2126458,The First Radiosynthesis Of New Potential Pet Agents For Imaging Of Pi3K And Mtor In Cancers
  作者:Wang,Min; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(4) 页码:1569-1574]
  
  6945-68-2 = 884495-39-0
  反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Water; Overnight,Rt2.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 2 H,Reflux3.1 Solvents: Methanol; Overnight,Rt4.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; Reflux
  标题:Alkylsulfonamide-Containing Quinazoline Derivatives As Potent And Orally Bioavailable Pi3Ks Inhibitors
  作者:Hei,Yuan-Yuan; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(20)]
  
  1072-97-5 = 884495-39-0
  反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid; 2 H,50 °C2.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Water; Overnight,Rt3.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 2 H,Reflux4.1 Solvents: Methanol; Overnight,Rt5.1 Reagents: Stannous Chloride Solvents: Ethyl Acetate; Reflux
  标题:Alkylsulfonamide-Containing Quinazoline Derivatives As Potent And Orally Bioavailable Pi3Ks Inhibitors
  作者:Hei,Yuan-Yuan; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(20)

海关参考信息

• 2905110000-甲醇
  2933310010-吡啶
  2909199090-其他醚及其衍生物
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管