CAS: 64191-14-6; (1S,2R)-2-Aminocyclopentane-1-Carboxylic Acid

相似化合物

64191-13-5 137170-89-9 143679-80-5

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📜1-环戊烯甲醛置于四氢吡咯,重铬酸吡啶,Palladium 10% On Activated Carbon,氢气体系中,用 甲醇,二氯甲烷,甲苯 作为反应溶剂,20.0~65.0 °C,6.08 Mpa 条件下,反应 124.0H,反应生成 (1S,2R)-2-氨基环戊烷甲酸
参考文献:α,β-二取代-β-氨基酸的立体选择性有机催化方法:一种短的对映选择性合成顺铂
标题:α,β-二取代-β-氨基酸的立体选择性有机催化方法:一种短的对映选择性合成顺铂
摘要:α-支链 α,β-不饱和醛已在有机催化串联迈克尔加成/与 N-(苄氧羰基)羟胺的环化中进行了测试,该反应迄今为止仅限于 α-未取代的烯醛.以环戊烯-2-甲醛为原料,并使用二苯基脯氨醇三甲基甲硅烷基醚作为手性胺催化剂,该方法开发了一种实用的,高产率(93-98% 总产率,三步)和高对映选择性(高达98:2 Er) 环状 β-氨基酸顺喷菌素的路线,与之前描述的这种生物活性天然产物的不对称合成相比具有优势.当使用无环 α-支链 α,β-不饱和醛作为底物时,反应产率取决于醛的取代模式,并获得顺式和反式异构体的混合物.
DOI:10.1002/ejoc.201300197

专利信息

专利号:US-8933227-B2
优先权日:2009-08-14
标题 :Selective synthesis of functionalized pyrimidines
发明人：LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN
权利人:LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for making 2,4-differentiated 5-trifluoromethyl pyrimidines and 2-amino-5-trifluoromethyl-pyrimidine derivatives, which compounds are useful in the preparation of pharmacologically active compounds.

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:WO-2007091110-A1
优先权日:2006-02-09
标 题 :Enzymatic resolution process for the preparation of cycli-c beta-amino acid and ester enatiomers
发明人：FORRO ENIKO; FUELOEP FERENC
权利人:UNIV SZEGEDI; FORRO ENIKO; FUELOEP FERENC
摘要:The invention relates to a process for the preparation of cyclic β-amino acid and ester enantiomers of general formula (I) wherein R is hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl and heteroaryl, wherein each ring may optionally be condensed; A is alkylene or alkenylene, and one or more carbon atoms of each groups may optionally be replaced with one or more heteroatoms; Rl and R2 are hydrogen or halogen, =(O)n, optionally halogenated alkyl, alkylidene, alkoxy, optionally protected hydroxy, optionally protected amino, mono- or dialkylamino and optionally substituted phenyl, or Rl and R2 taken together with one or any two atoms of the ring to which they are attached, form a saturated, unsaturated or aromatic fused homo- or heterocyclic ring; n is 0, 1 or 2; * denotes a chiral carbon atom; and the salts thereof, comprising the steps of hydrolysing a mixture of cyclic β-amino ester enantiomers with a stereoselective hydrolytic enzyme, and separating the obtained acid enantiomer and the unreacted ester enantiomer. The invention provides an enzymatic resolution procedure for the preparation of enantiomers of both the cis- and trans-cyclic β-amino acids and esters useful for the synthesis ' of biologically active agents.

专利号:US-2011190499-A1
优先权日:2009-08-14
标题 :Selective synthesis of functionalized pyrimidines

专利号:US-2024207458-A1
优先权日:2021-04-26
标 题:Targeted alpha particle therapy for somatostatin receptor 2 positive neuroendocrine tumors and metastases
发明人：MORSE DAVID; JI HAITAO; WADAS THADDEUS; PANDYA DARPAN
权利人:H LEE MOFFITT CANCER CT & RES
摘要:Disclosed are TATE derivatives having a linker between the TATE moiety and a macrocyclic radionuclide chelating moiety. Methods of synthesis and use are also disclosed. The compounds preferably exhibit a ratio of kidney: liver uptake by a subject within 24 hours of 5 or less, 3 or less, 1 or less, 0.5 or less, preferably from 2:1 to 1:2.

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.