CAS: 512-85-6; 1-Isopropyl-4-Methyl-2,3-Dioxabicyclo[2.2.2]Oct-5-Ene

该化合物是一种化学化合物,被归类为单体,主要来自某些植物,特别是Chenopodiaceae家族的植物的基本油,以其结构特征而著称,包括环丙烷环环的双环框架;阿斯卡里多尔因其潜在的生物活动而得到承认,包括非甲状腺特性,因此对药用化学和药理学感兴趣;该化合物一般没有颜色,可粉色黄色液体,具有独特的气味;它溶于有机溶剂中,但水溶性有限;对阿斯卡里多尔进行了研究,研究其对于各种生物系统的影响,并记录了其在传统医学中的使用情况;然而,应当象任何化学物质一样,特别是在治疗环境中使用的任何化学物质一样,考虑其安全和毒性特征.

结构式图片

MSDS等安全信息

    上下游产品

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    合成工艺路线路线简述

    • 合成目标产物 Ascaridole 主要起始原料 Alpha-Terpinene
    • (文献来源)合成步骤主要原料 Alpha-Terpinene
    📜4-异丙基甲苯置于sodium Molybdate,Sodium Dodecyl-Sulfate,正丁醇体系中,用 乙酸乙酯 作为反应溶剂,化学反应生成 阿斯利多
    参考文献:环保型微乳液中疏水性底物的"深色"单线态氧合
    标题:环保型微乳液中疏水性底物的"深色"单线态氧合
    摘要:在无氯无水微乳液中,钼酸盐催化的过氧化氢使疏水化合物的"暗"单线态氧合反应有效进行,催化剂负载量低(10-3 Mol%).这些微非均相系统由十二烷基硫酸钠(sds)/正丁醇/水/有机相组成,后者是"绿色"溶剂(例如乙酸乙酯)或液体底物(例如α-松油烯或β-香茅醇.对于这种液体底物的"暗"单重态氧合,可以获得非常高的反应器产率和更高的产物/ Sds比.
    DOI:10.1002/1615-4169(200202)344:2<184::Aid-Adsc184>3.0.Co;2-Y

    海关参考信息

    专利信息


    专利号:US-7947701-B2
    优先权日:2003-11-14
    标题:Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof
    发明人:CAZELLES JEROME; COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN
    权利人:SANOFI AVENTIS
    摘要:The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.

    专利号:WO-2024130393-A1
    优先权日:2022-12-21
    标 题 :Nanoparticle and method of synthesis thereof
    发明人:MOSKOVCHENKO SVITLANA
    权利人:MOSKOVCHENKO SVITLANA
    摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

    专利号:US-5053559-A
    优先权日:1989-12-29
    标题:Cleavage of 1,2,4-trioxanes
    发明人:JEFFORD CHARLES W
    权利人:OXACO SA
    摘要:1,2,4-Trioxanes are subjected to reductive cleavage, thereby to produce a 1,2-diol and carbonyl compound. The process has applications both in the synthesis of 1,2-diols and the protection, in the course of organic synthesis, of carbonyl compounds.

    专利号:US-4239929-A
    优先权日:1978-11-01
    标题 :Aromatization of dienes in the liquid phase
    发明人:MASILAMANI DIVAKARAN; ROGIC MILORAD M
    权利人:ALLIED CHEM
    摘要:Alkyl cyclohexa-1,3-dienes are aromatized with sulfur dioxide and oxygen. Cyclohexa-1,4-dienes are aromatized with sulfur dioxide. Conjugated dienic hydrocarbons, including alkyl cyclohexa-1,3-dienes, are converted to beta-olefinic peroxides by sulfur dioxide and oxygen. The aromatization reactions are useful as part of the synthesis of selected aromatics from acyclic olefins. The beta-olefinic peroxides are useful intermediates in the production of 1,4-diols.

    专利号:GB-2539442-A
    优先权日:2015-06-16
    标 题:New synthesis of tapentadol-HCI intermediates

    专利号:GB-630284-A
    优先权日:1946-03-23
    标题:Synthesis of penicillin

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Monzote L, Geroldinger G, Tonner M, Scull R, De Sarkar S, Bergmann S, Bacher M, Staniek K, Chatterjee M, Rosenau T, Gille L. Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes. Phytother Res. 2018 Apr 19. doi: 10.1002/ptr.6097. [Epub ahead of print] doi: 10.1007/s11356-017-0267-9. Epub 2017 Oct 1. doi: 10.1016/j.bcp.2017.02.023. Epub 2017 Mar 2. doi: 10.1016/j.foodchem.2016.10.006. Epub 2016 Oct 4. doi: 10.1016/j.exppara.2016.10.008. Epub 2016 Nov 1. doi: 10.1021/acs.chemrestox.6b00157. Epub 2016 Aug 24. doi: 10.1111/cod.12591. Epub 2016 May 13. Review. doi: 10.1371/journal.pone.0141886. eCollection 2015.
    9: Zhao Q, Gao B, Ma L, Lian J, Deng L, Chen J. Innovative intragastric ascaridole floating tablets: Development, optimization, and in vitro-in vivo evaluation. Int J Pharm. 2015 Dec 30;496(2):432-9. doi: 10.1016/j.ijpharm.2015.10.007. Epub 2015 Oct 8. doi: 10.1093/toxsci/kfv148. Epub 2015 Jul 15. doi: 10.1002/bmc.3479. Epub 2015 Apr 21. doi: 10.1016/j.actatropica.2015.02.002. Epub 2015 Feb 17. doi: 10.1080/14786419.2014.988714. Epub 2014 Dec 11. doi: 10.1080/14786419.2014.965167. Epub 2014 Nov 27. doi: 10.1016/j.phymed.2014.03.002. Epub 2014 Apr 24. doi: 10.1155/2014/930208. Epub 2014 Mar 16.
    17: Christoffers WA, Blömeke B, Coenraads PJ, Schuttelaar ML. The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil. Contact Dermatitis. 2014 Sep;71(3):129-37. doi: 10.1111/cod.12199. Epub 2014 Mar 20. doi: 10.1186/1756-3305-6-337.

    合成参考文献


    摘要:Telmesani, R.; Sun, A. C.; Beeler, A. B.; Stephenson, C. R. J., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 119.
    摘要:Zhang, C.; Duan, Y.-N., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
    参考文献:10.1007/s001050100212
    摘要:Schempp CM, Schöpf E, Simon JC. [Plant-induced toxic and allergic dermatitis (phytodermatitis)]. Hautarzt. 2002 Feb;53(2):93–7. doi: 10.1007/s001050100212.
    参考文献:10.1021/np010445g
    摘要:Kiuchi F, Itano Y, Uchiyama N, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T. Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides. J Nat Prod. 2002 Apr;65(4):509–12. doi: 10.1021/np010445g.
    参考文献:10.1016/j.ijpharm.2015.10.007
    摘要:Zhao Q, Gao B, Ma L, Lian J, Deng L, Chen J. Innovative intragastric ascaridole floating tablets: Development, optimization, and in vitro–in vivo evaluation. International Journal of Pharmaceutics. 2015 Dec;496(2):432–9. doi: 10.1016/j.ijpharm.2015.10.007.
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