CAS: 5058-13-9; (S)-2-(2-Oxo-8,9-Dihydro-2H-Furo[2,3-H]Chromen-8-yl)Propan-2-Yl (Z)-2-Methylbut-2-Enoate
该化合物是一种天然化合物,被归类为科马林衍生物,主要取自各种植物来源,特别是原产物* MIKANIA* 的植物来源,该化合物以其潜在的生物活动而著称,包括抗炎,抗氧化剂和抗微生物特性.哥伦比亚纳丁州展示了典型的科马林特有的芳香结构,有助于其再活动以及与生物系统的互动.该化合物经常因其药理学潜力而进行研究,特别是在传统医学方面.其溶性性和稳定性可能因溶剂和环境条件而异,因此在实验应用中必须考虑到这些因素.与许多天然产品一样,目前正在进一步研究,以充分阐明其行动和潜在治疗用途的机制.
- 英文名称(S)-2-(2-Oxo-8,9-Dihydro-2H-Furo[2,3-H]Chromen-8-yl)Propan-2-Yl (Z)-2-Methylbut-2-Enoate
- 中文名称二氢欧山芹醇当归酸酯
- IUPAC名称(S)-2-(2-oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-methylbut-2-enoate
- 其它别名2-Butenoic Acid, 2-Methyl-, 1-(8,9-Dihydro-2-Oxo-2H-Furo(2,3-H)-1-Benzopyran-8-yl)-1-Methylet- Hyl Ester, (S-(Z))-; 2-[(8S)-2-Oxo-8,9
- CAS编号5058-13-9
- MFCD编号:MFCD07781426
- 分子式:C19H20O5分子量:328.36
- 产品CID: 1493804
- 产品分类生物化工 → 提取物
物理性质
- 熔点166 °C
- 沸点482.3±45.0 °C at 760 mmHg
- 闪点212.7±28.8 °C
- 密度1.2±0.1 g/cm3
- PSA:65.74
- LogP:3.95
- 折射率1.569
- 蒸汽压0.0±1.2 mmHg at 25°C
- 溶解性DMSO : 33.33 mg/mL (101.50 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 外观形态固体;White to Almost white powder to crystal
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是安杰利卡脱菌(UMBELLIFERRAE)的天然科马林,已知CBEN有各种生物活动,包括防炎和抗癌效果.
MSDS等安全信息
- 警示词Warning
- 危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 安全声明24/25
上下游产品
columbianetin (Z)-2-methyl-2-butenoic anhydride Angelic acid合成工艺路线路线简述
📜依替前列通置于caesium Carbonate,N,N'-二环己基碳二亚胺体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene,二氯甲烷,乙腈 作为反应溶剂,化学反应 2.0H,反应生成 二氢欧山芹醇当归酸酯
参考文献:Semisynthesis Of Ingenol 3-Angelate (Pep005): Efficient Stereoconservative Angeloylation Of Alcohols
标题:Semisynthesis Of Ingenol 3-Angelate (Pep005): Efficient Stereoconservative Angeloylation Of Alcohols
摘要:A High-Yielding Method Was Developed For The Preparation Of Ingenol 3-Angelate (Pep005,Ingenol Mebutate) Via The Corresponding 5,20-Acetonide Without Concomitant Isomerization Of The Angelate (Z-Form) To The Corresponding Tiglate (E-Form). The General Scope Of The Stereoconservative Esterification Method Was Further Evaluated On Several Different Alcohols,Giving The Angelates In Up To Quantitative Yield Without Isomerization To The Tiglate.
DOI:10.1055/s-0032-1317415
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Yang YF, Zhang L, Yang XW. Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis. Molecules. 2018 Jan 20;23(1). pii: E225. doi: 10.3390/molecules23010225. doi: 10.1016/j.jchromb.2017.06.020. Epub 2017 Jun 13. doi: 10.1016/j.jep.2016.11.046. Epub 2016 Nov 30. doi: 10.4268/cjcmm20161214. Chinese. doi: 10.1002/cbdv.201500198. Epub 2016 May 24. doi: 10.4062/biomolther.2015.145.
7: Yang YF, Xu W, Song W, Ye M, Yang XW. Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer-An in Vitro Model for Blood-Brain Barrier Permeability. Molecules. 2015 Jun 25;20(7):11719-32. doi: 10.3390/molecules200711719. doi: 10.1002/bmc.3543. Epub 2015 Aug 17. doi: 10.1186/s13065-014-0064-1. eCollection 2014.
10: Sarkhail P. Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: a review. J Ethnopharmacol. 2014 Oct 28;156:235-70. doi: 10.1016/j.jep.2014.08.034. Epub 2014 Sep 3. Review. doi: 10.1016/j.jep.2014.07.033. Epub 2014 Jul 25. doi: 10.1002/bmc.2927. Epub 2013 May 30. doi: 10.1016/j.phytochem.2012.06.015. Epub 2012 Jul 9. doi: 10.1016/j.fitote.2010.12.007. Epub 2010 Dec 24. doi: 10.1002/bmc.1310. doi: 10.3736/jcim20080413. Chinese. Chinese. Chinese. Epub 2005 Oct 17. Epub 2004 Aug 21.
合成参考文献
摘要:Wu YN, Luan LB. [In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis]. Yao Xue Xue Bao. 2008 Jan;43(1):102–7.
参考文献:10.1007/s00216-004-2795-7
摘要:Tammela P, Wennberg T, Vuorela H, Vuorela P. HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Analytical and Bioanalytical Chemistry. 2004 Aug 21;380(4):614–8. doi: 10.1007/s00216-004-2795-7.
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