CAS: 48149-72-0; Ally A-D-Galactopyranoside

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D-Galactose allyl alcohol D-Galactose-dibenzyldithioacetal D-Galactose 2,3,4,6-tetra-O-acetyl-1-O-allyl-α-D-galactopyranoside allyl 4,6-O-benzylidene-α-D-galactopyranoside 1-O-Allyl 6-O-trityl-α-D-galactopyranoside -α-D-galactopyranosideallyl 3-O-(p-methoxyphenyl)methyl-α-D-galactopyranoside

📜2,3,4,6-Tetra-O-Acetyl-1-O-Allyl-α-D-Galactopyranoside置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,反应生成 烯丙基-α-D-吡喃半乳糖苷
参考文献:糖基醛:通过生物正交肟键形成合成新糖缀合物的新支架.
标题:糖基醛:通过生物正交肟键形成合成新糖缀合物的新支架.
摘要:作为bürgenstock专栏2017年有机化学中的未来之星的一部分发布 抽象的 通过肟(或)键形成直接制备糖基新缀合物代表了化学生物学中的关键生物正交工具.然而,当通过使聚糖部分的还原端反应而采用该策略时,由于聚糖环状半缩醛的部分(或完全)开放和相应的开放互变异构体的形成而失去了构型和立体化学信息.我们已经完成了糖基醛文库的合成,该文库用作通过肟键形成合成新糖缀合物的骨架.这些糖基醛构成了一种简单易用的替代方法,可避免在通过肟(或bonds)键结合天然碳水化合物的还原端所存在的醛官能度时,避免手性信息的丢失. 通过肟(或)键形成直接制备糖基新缀合物代表了化学生物学中的关键生物正交工具.然而,当通过使聚糖部分的还原端反应而采用该策略时,由于聚糖环状半缩醛的部分(或完全)开放和相应的开放互变异构体的形成而失去了构型和立体化学信息.我们已经完成了糖基醛文库的合成,该文库用作通过肟键形成合成新糖
DOI:10.1055/s-0036-1591082

专利信息

专利号:US-5620902-A
优先权日:1987-12-02
标题 :Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
发明人：RATCLIFFE ROBERT M; VENOT ANDRE P; ABBAS S ZAHEER
权利人:ALBERTA RES COUNCIL
摘要:The stereochemistry of sialylation of an acceptor saccharide to obtain an α (2-3) or α (2-6) linkage is controlled to favor the α anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate α (2-3) and α (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.

专利号:US-5344870-A
优先权日:1987-12-02
标 题 :Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
发明人：RATCLIFFE ROBERT M; VENOT ANDRE P
权利人:ALBERTA RES COUNCIL
摘要:The stereochemistry of sialylation of an acceptor saccharide to obtain an α (2-3) or α (2-6) linkage is controlled to favor the α anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate α (2-3) and α (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.