CAS: 402-52-8; 1-Methoxy-4-(Trifluoromethyl)Benzene

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CAS号402-45-9 4-(三氟甲基)苯酚 | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号98-56-6 4-氯三氟甲苯 | CAS号402-43-7 对溴三氟甲苯 | CAS号1027513-97-8 ALPHA,ALPHA-二氟-... | CAS号696-62-8 4-碘苯甲醚 | CAS号77152-08-0 copper(1+),trif... | CAS号5720-07-0 4-甲氧基苯硼酸 | CAS号383-63-1 三氟乙酸乙酯 | CAS号402-10-8 2-溴-1-甲氧基-4-(三氟甲基)苯 | CAS号503464-99-1 1-(2-甲氧基-5-三氟甲基苯基)乙酮 | CAS号5396-38-3 4-叔丁基茴香醚 | CAS号146539-83-5 2-甲氧基-5-(三氟甲基)苯甲醛 | CAS号349-67-7 2-甲氧基-5-三氟甲基苯酚 | CAS号4864-01-1 2-甲氧基-5-三氟甲基苯甲酸 | CAS号240139-82-6 2-甲氧基-5-(三氟甲基)苯基硼酸 | CAS号72083-15-9 [2-methoxy-5-(t... | CAS号67589-15-5 1-(2-羟基-5-(三氟甲基... | CAS号97067-18-0 4-甲基-4-三氟甲基-联苯

2,2-二氟-2-(4-甲氧基苯基)乙酸乙酯置于potassium Carbonate,Silver Nitrate,Selectfluor体系中,用 甲醇,水,丙酮 作为反应溶剂,化学反应 3.0H,反应生成 4-三氟甲基苯甲醚
参考文献:Catalytic Decarboxylative Fluorination For The Synthesis Of Tri-And Difluoromethyl Arenes
标题:Catalytic Decarboxylative Fluorination For The Synthesis Of Tri-And Difluoromethyl Arenes
摘要:Treatment Of Readily Available Alpha,Alpha-Difluoro-And Alpha-Fluoroarylacetic Acids With Selecffluor Under Ag(I) Catalysis Led To Decarboxylative Fluorination. This Operationally Simple Reaction Gave Access To Tri-And Difluoromethylarenes Applying A Late-Stage Fluorination Strategy. Translation To [f-18]Labeling Is Demonstrated Using [f-18]Selectfluor Bis(Triflate),A Reagent Affording [f-18]Tri-And [f-18]Difluoromethylarenes Not Within Reach With [f-18]F-2.
DOI:10.1021/ol4009377

专利信息

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-2023099421-A1
优先权日:2019-12-17
标题 :A new method of 18f labelling and intermediate salts
发明人：YOUNG ROWAN DRURY; MANDAL DIPENDU; GUPTA RICHA; JAISWAL AMIT KUMAR
权利人:NAT UNIV SINGAPORE
摘要:Disclosed herein is a salt of formula I: where R 1 , X, n, R, R 1 , Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET & imaging, as well as methods to make the compounds of formula I.

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-4996314-A
优先权日:1986-03-11
标题 :6-(disubstituted amino)carbapenem compounds
发明人：YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI
权利人:SANRAKU INC
摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

专利号:US-11279687-B2
优先权日:2010-09-03
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; YUEN PO-WAI
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.