CAS: 38092-89-6; 8-Chloro-11-(1-Methylpiperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine

相似化合物

38092-89-6 117810-61-4 117796-52-8

上下游产品

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8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-B]吡啶-11-酮置于硫酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.5H,反应生成 8-氯-6,11-二氢-11-(1-甲基-4-哌啶叉)-5H-苯并[5,6]环庚烷[1,2-B]吡啶
参考文献:含有苯并[5,6]环庚[1,2-B]吡啶部分作为潜在抗肿瘤和抗炎药的硫脲衍生物的设计与合成
标题:含有苯并[5,6]环庚[1,2-B]吡啶部分作为潜在抗肿瘤和抗炎药的硫脲衍生物的设计与合成
摘要:开发了硫脲衍生物(6A-E)并筛选了抗肿瘤和抗炎活性.大多数化合物在体外对乳腺(mcf-7和mda-Mb 231)以及结肠(ht-29)癌细胞的生长抑制作用与5-氟尿嘧啶相当.在二甲苯诱导的小鼠耳部肿胀试验中,它们在体内的抗炎活性也比布洛芬强.
DOI:10.1016/j.Bmcl.2012.03.002

专利信息

专利号:WO-2023071601-A1
优先权日:2021-10-28
标题:Desloratadine derivative, preparation method therefor and application thereof
发明人：YAO CHEN
权利人:TIANJIN NEWSUN INVEST DEVELOPMENT CO LTD
摘要:Disclosed in the present application is a compound as represented by formula (A), wherein-R is-R' or -Y-(CH 2 ) n -R', Y is O or NH, n is 1, 2, 3, 4, 5 or 6, and -R' is diethylamino, pyrrolidinyl, piperazinyl, N-morpholinyl, bis(2-methoxyethyl)amino or 4-methylpiperazinyl. Also disclosed are a synthesis method for the compound shown, and use of the compound shown in the preparation of drugs for relieving or treating or preventing allergy and related symptoms thereof.

专利号:ES-2257467-T3
优先权日:2000-11-23
标 题 :NEW SALTS OF DESLORATADINE, PROCESS FOR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME.