CAS: 3493-13-8; ((S)-3-Amino-3-Carboxypropyl)(((2S,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl)(Methyl)Sulfonium Iodide

上下游产品

CAS号74-88-4 碘甲烷 | CAS号979-92-0 S-腺苷-L-高半胱氨酸

📜碘甲烷,S-(5'-腺苷)-L-高半胱氨酸置于anion Methyltransferase From Aspergillus Clavatus体系中,化学反应 20.0H,反应生成 S-腺苷基-L-蛋氨碘盐
参考文献:用于从卤代烷烃中混杂合成 S-腺苷甲硫氨酸类似物的阴离子甲基转移酶的底物分析
标题:用于从卤代烷烃中混杂合成 S-腺苷甲硫氨酸类似物的阴离子甲基转移酶的底物分析
摘要:普遍存在的共底物s-腺苷甲硫氨酸 (Sam) 的非天然类似物难以获得,但可用于具有高选择性的各种分子的酶促功能化.我们研究了阴离子甲基转移酶家族中 Sam 类似物的混杂合成.已鉴定出几种混杂酶,它们可从廉价且容易获得的卤代烷烃合成非天然共底物.这为选择性烷基化化学开辟了新途径.
DOI:10.1002/cbic.202100632

专利信息

专利号:US-10391166-B2
优先权日:2013-02-18
标 题:Short oligonucleotides as vaccine adjuvants and therapeutic agents
发明人：IYER RADHAKRISHNAN P
权利人:SPRING BANK PHARMACEUTICALS INC; SPRING BREAK PHARMACEUTICALS INC
摘要:The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.