CAS: 2979-22-8; 2-Methoxy-2-Phenylethanol

该化合物是一种有机化合物,其特征是附于苯乙烯环的甲氧基(-OCH)和羟基(-OH)组;该化合物一般是一种无色的黄色液体,其香味和花粉味一般是粉色的黄色液体;在乙醇和乙醚等有机溶剂中可溶解,但由于其水分疏松芳香结构,其溶解性有限; -甲基氧苯基乙醇在香气工业中的用途为已知,用作香气剂,并用作各种有机化合物的合成; 甲基氧基和氢氧基组的存在有助于其再活性,使其得以参与各种化学反应,包括氧化和化; 此外,它表现出微量的微量特性,使其在某些药品和化妆品配方中引起兴趣; 处理和接触安全数据,如任何化学物质一样,应当用于处理和接触准则.

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CAS号7021-09-2 DL-alpha-甲氧基苯乙酸 | CAS号96-09-3 氧化苯乙烯 | CAS号67-56-1 甲醇 | CAS号292638-84-7 phenylene-ethylene | CAS号3558-61-0 甲氧基苯乙酸甲酯 | CAS号37011-27-1 (2-methoxy-2-ph... | CAS号93-56-1 (±)-1-苯基-1,2-乙二醇 | CAS号124-41-4 甲醇钠 | CAS号186581-53-3 重氮甲烷 | CAS号91970-57-9 (2-methoxy-1-ph...

合成工艺路线路线简述

    📜甲氧基苯乙酸甲酯置于lithium Aluminium Tetrahydride体系中,化学反应生成2-甲氧基-2-苯乙醇
    参考文献:Neighboring Carbon And Hydrogen. Xvii. The Pinacol Rearrangement. Solvolysis Of 2-Methoxy-2-Phenylethyl And Related Halides1,2
    标题:Neighboring Carbon And Hydrogen. Xvii. The Pinacol Rearrangement. Solvolysis Of 2-Methoxy-2-Phenylethyl And Related Halides1,2
    摘要:
    Doi:10.1021/ja01612A006

    海关参考信息

    专利信息


    专利号:US-6555686-B2
    优先权日:2000-03-23
    标题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors
    发明人:PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A
    权利人:BRISTOL MYERS SQUIBB PHARMA
    摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

    专利号:US-7122693-B2
    优先权日:1988-04-11
    标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
    发明人:BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
    权利人:SHIRE BIOCHEM INC
    摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

    专利号:US-3910965-A
    优先权日:1971-11-29
    标 题 :Process for the preparation of 2-formylcyclopentane derivatives
    发明人:SAKAI KIYOSHI; KOJIMA KOICHI; YUSA TAKASHI; KATANO HAMAKO
    权利人:SANKYO CO
    摘要:A process for the preparation of 2-formylcyclopentane derivatives having the formula WHEREIN A represents a straight or branched alkylene group having 1*8 carbon atoms, Z represents cyano group, carbamoyl group, carboxyl group or an alkoxycarbonyl group having 1*6 carbon atoms in the alkyl moiety and R represents a tetrahydropyranyl group or an alkoxyalkyl group having 1*6 carbon atoms in each alkyl moiety or its optical isomer or the racemic mixture thereof which comprises conntacting a 2hydroxymethylcyclopentane derivative having the formula WHEREIN A, Z and R are the same as above or its optical isomer or the racemic mixture thereof with an oxidizing agent in the presence of a solvent at the temperature ranging from -30*C to room temperature. The 2-formylcyclopentane derivatives are useful as intermediates for synthesis of prostaglandin F Alpha .

    专利号:US-5087716-A
    优先权日:1990-01-22
    标 题:Novel synthesis of difunctional halo organo noncarbon group IV main group element amides
    发明人:WRIGHT ANTONY P; VARAPRATH PADMAKUMARI J
    权利人:DOW CORNING
    摘要:Difunctional halo silicon amide compounds are prepared by cleaving the nitrogen-silicon bond in a nitrogen-silicon heterocycle with a reactive halide. The reaction is straight forward with no intermediates or byproducts. The halo functionality is capable of capping any SiOH group. When the other functionality is an acrylamide, the capped entity may be polymerized or crosslinked by free radical initiators of the acrylamide functionality thereby producing useful products such as paper release coatings and photoresists.

    专利号:US-5017717-A
    优先权日:1990-01-22
    标 题:Novel synthesis of difunctional halo organo noncarbon group IV main group element amides
    发明人:WRIGHT ANTONY P; VARAPRATH PADMAKUMARI J
    权利人:DOW CORNING
    摘要:Difunctional halo silicon amide compounds are prepared by cleaving the nitrogen-silicon bond in a nitrogen-silicon heterocycle with a reactive halide. The reaction is straight forward with no intermediates or byproducts. The halo functionality is capable of capping any SiOH group. When the other functionality is an acrylamide, the capped entity may be polymerized or crosslinked by free radical initiators of the acrylamide functionality thereby producing useful products such as paper release coatings and photoresists.

    专利号:WO-2011095125-A1
    优先权日:2010-02-02
    标 题:Synthesis methods and purification methods of dasatinib
    发明人:YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
    权利人:NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD; YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
    摘要:Synthesis methods of dasatinib are provided, which comprise the following steps: reacting a compound of formula I with a compound of formula II to obtain a compound of formula III, and then connecting the compound of formula III with 2-chloro-6-methylaniline and 1-(2-hydroxyethyl)piperazine in any order to give dasatinib. Furthermore, purification methods of dasatinib are also provided.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: S Goldmann, Et Al. Determination Of The Absolute Configuration Of The Active Amlodipine Enantiomer As (-)-S: A Correction. J Med Chem. 1992 Sep 4;35(18):3341-4.

    合成参考文献


    摘要:Kleoff, M.; Omoregbee, K.; Zimmer, R., Science of Synthesis Knowledge Updates, (2018) 4, 211.
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