📜甲氧基苯乙酸甲酯置于lithium Aluminium Tetrahydride体系中,化学反应生成2-甲氧基-2-苯乙醇 参考文献:Neighboring Carbon And Hydrogen. Xvii. The Pinacol Rearrangement. Solvolysis Of 2-Methoxy-2-Phenylethyl And Related Halides1,2 标题:Neighboring Carbon And Hydrogen. Xvii. The Pinacol Rearrangement. Solvolysis Of 2-Methoxy-2-Phenylethyl And Related Halides1,2 摘要: Doi:10.1021/ja01612A006
专利号:US-6555686-B2 优先权日:2000-03-23 标题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors 发明人:PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A 权利人:BRISTOL MYERS SQUIBB PHARMA 摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.
专利号:US-7122693-B2 优先权日:1988-04-11 标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof 发明人:BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE 权利人:SHIRE BIOCHEM INC 摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.
专利号:US-3910965-A 优先权日:1971-11-29 标 题 :Process for the preparation of 2-formylcyclopentane derivatives 发明人:SAKAI KIYOSHI; KOJIMA KOICHI; YUSA TAKASHI; KATANO HAMAKO 权利人:SANKYO CO 摘要:A process for the preparation of 2-formylcyclopentane derivatives having the formula WHEREIN A represents a straight or branched alkylene group having 1*8 carbon atoms, Z represents cyano group, carbamoyl group, carboxyl group or an alkoxycarbonyl group having 1*6 carbon atoms in the alkyl moiety and R represents a tetrahydropyranyl group or an alkoxyalkyl group having 1*6 carbon atoms in each alkyl moiety or its optical isomer or the racemic mixture thereof which comprises conntacting a 2hydroxymethylcyclopentane derivative having the formula WHEREIN A, Z and R are the same as above or its optical isomer or the racemic mixture thereof with an oxidizing agent in the presence of a solvent at the temperature ranging from -30*C to room temperature. The 2-formylcyclopentane derivatives are useful as intermediates for synthesis of prostaglandin F Alpha .
专利号:US-5087716-A 优先权日:1990-01-22 标 题:Novel synthesis of difunctional halo organo noncarbon group IV main group element amides 发明人:WRIGHT ANTONY P; VARAPRATH PADMAKUMARI J 权利人:DOW CORNING 摘要:Difunctional halo silicon amide compounds are prepared by cleaving the nitrogen-silicon bond in a nitrogen-silicon heterocycle with a reactive halide. The reaction is straight forward with no intermediates or byproducts. The halo functionality is capable of capping any SiOH group. When the other functionality is an acrylamide, the capped entity may be polymerized or crosslinked by free radical initiators of the acrylamide functionality thereby producing useful products such as paper release coatings and photoresists.
专利号:US-5017717-A 优先权日:1990-01-22 标 题:Novel synthesis of difunctional halo organo noncarbon group IV main group element amides 发明人:WRIGHT ANTONY P; VARAPRATH PADMAKUMARI J 权利人:DOW CORNING 摘要:Difunctional halo silicon amide compounds are prepared by cleaving the nitrogen-silicon bond in a nitrogen-silicon heterocycle with a reactive halide. The reaction is straight forward with no intermediates or byproducts. The halo functionality is capable of capping any SiOH group. When the other functionality is an acrylamide, the capped entity may be polymerized or crosslinked by free radical initiators of the acrylamide functionality thereby producing useful products such as paper release coatings and photoresists.
专利号:WO-2011095125-A1 优先权日:2010-02-02 标 题:Synthesis methods and purification methods of dasatinib 发明人:YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG 权利人:NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD; YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG 摘要:Synthesis methods of dasatinib are provided, which comprise the following steps: reacting a compound of formula I with a compound of formula II to obtain a compound of formula III, and then connecting the compound of formula III with 2-chloro-6-methylaniline and 1-(2-hydroxyethyl)piperazine in any order to give dasatinib. Furthermore, purification methods of dasatinib are also provided.
[参考文献]: S Goldmann, Et Al. Determination Of The Absolute Configuration Of The Active Amlodipine Enantiomer As (-)-S: A Correction. J Med Chem. 1992 Sep 4;35(18):3341-4.
合成参考文献
摘要:Kleoff, M.; Omoregbee, K.; Zimmer, R., Science of Synthesis Knowledge Updates, (2018) 4, 211.