CAS: 288315-03-7; 3,3-Difluoroazetidine Hydrochloride

相似化合物

617718-46-4 1427379-42-7 1255666-59-1

3,3-二氟氮杂环丁烷-1-羧酸叔丁酯置于盐酸体系中,用 水,乙酸乙酯 用作溶剂,以93%的收率获得3,3-二氟三甲叉亚胺 盐酸盐
参考文献:带有氟化四元杂环的高能材料:3,3'-二氟氮杂环丁烷(dfaz)盐†
标题:带有氟化四元杂环的高能材料:3,3'-二氟氮杂环丁烷(dfaz)盐†
摘要:3,3'-二氟氮杂环丁烷(dfaz)具有高强度的四元环和氟原子,有助于特定的脉冲,爆轰压力和爆轰速度.合成了含有富氧阴离子和阳离子的高密度高能盐.所有的盐都通过红外光谱,单晶x射线衍射,元素分析,差示扫描量热法(dsc)以及冲击和摩擦敏感性进行了全面表征.根据形成的密度和热量计算其爆轰性能.结果表明,与adn相比,它们都具有相对较高的密度和较低的冲击敏感性.几乎所有盐的比冲都比推进剂成分二硝酰胺铵(adn,I Sp= 202 J).此外,3,3'-二氟氮杂环丁烷硝酸甲酸酯盐具有最高的比冲,并且相对更稳定.通过将四元高压环与氟原子结合,可以获得具有非常好性能的高能阳离子.
Doi:10.1039/c9Nj02569C

专利信息

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-2016016916-A1
优先权日:2013-03-15
标 题:Exo Olefin-Containing Nuclear Transport Modulators and Uses Thereof
发明人：SANDANAYAKA VINCENT P; SHECHTER SHARON; DAELEMANS DIRK; LEEN VOLKER; DEHAEN WIM ALFRONS; SHACHAM SHARON
权利人:KARYOPHARM THERAPEUTICS INC; KATOLIEKE UNIVERSITEIT LEUVEN
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and, more particularly, to a compound represented by structural formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

专利号:US-9714226-B2
优先权日:2011-07-29
标题:Hydrazide containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; MCCAULEY DILARA; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: n nor a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.