CAS: 27973-72-4; (+)-Pederine

上下游产品

(+)-Dibenzoylpederin 123483-10-3
[(1S)-2-[[(S)-[(2S,4R,6R)-6-[(2S)-2,3-Dimethoxypropyl]-5,5-Dimethyl-4-Triethylsilyloxyoxan-2-Yl]-Methoxymethyl]Amino]-1-[(2R,5R,6R)-2-Methoxy-5,6-Dimethyl-4-Methylideneoxan-2-Yl]-2-Oxoethyl] Benzoate 1271737-46-2
[(1S)-2-[[(S)-[(2S,4R,6R)-6-[(2S)-2,3-Dimethoxypropyl]-5,5-Dimethyl-4-Trimethylsilyloxyoxan-2-Yl]-Methoxymethyl]-(2-Trimethylsilylethoxycarbonyl)Amino]-1-[(2R,5R,6R)-2-Methoxy-5,6-Dimethyl-4-Methylideneoxan-2-Yl]-2-Oxoethyl] Benzoate 956117-56-9
(S)-2-(Benzoyloxy)-2-((2R,5R,6R)-Tetrahydro-2-Methoxy-5,6-Dimethyl-4-Methylene-2H-Pyran-2-yl)Acetic Acid 175085-05-9
(S)-2-Chloro-1-((2R,5R,6R)-2-Methoxy-5,6-Dimethyl-4-Methylenetetrahydro-2H-Pyran-2-yl)-2-Oxoethyl Benzoate 956117-45-6

📜(2S,4R,6R)-6-((S)-2-Hydroxy-3-Methoxypropyl)-5,5-Dimethyl-4-((Triethylsilyl)Oxy)Tetrahydro-2H-Pyran-2-Carbonitrile置于schwartz'S Reagent,2,6-二叔丁基吡啶,Magnesium(II) Perchlorate,四丁基氟化铵,Lithium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水 用作溶剂,化学反应 0.75H,反应生成隐翅虫毒素
参考文献:Pederin,Psymberin 和高效类似物的全合成和生物学评价
标题:Pederin,Psymberin 和高效类似物的全合成和生物学评价
摘要:有效的细胞毒素 Pederin 和 Psymberin 是通过简洁的合成路线(最长线性序列中分别为 10 和 14 步)制备的,这些路线通过后期多组分方法构建 N-酰基氨基键.该路线允许轻松制备许多类似物,这些类似物旨在探索 N-酰基氨基中的烷氧基和两个主要亚基中的官能团对生物活性的重要性.这些类似物,包括 Pederin/psymberin 嵌合体,分析了它们的生长抑制作用,揭示了几种新的有效细胞毒素,并导致关于生物活性所需的分子构象和氢键模式的假设.第二代类似物已根据初始测定的结果和这些化合物与核糖体结合的基于结构的模型制备.报道了这些化合物的生长抑制特性.这些研究表明,一般的有机化学,特别是后期多组分反应,在开发独特而有效的生物反应效应物方面可以发挥深远的作用.
Doi:10.1021/ja207331M

专利信息

专利号:US-8148102-B2
优先权日:2007-02-08
标题 :Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs
发明人：CHENG YI-QIANG
权利人:CHENG YI-QIANG; UWM RES FOUNDATION INC
摘要:Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.

专利号:US-9611491-B2
优先权日:2010-04-15
标 题:Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
发明人：SHERMAN DAVID H; EHRLICH GARTH D; JANTO BENJAMIN; WILLIAMS ROBERT M; RATH CHRISTOPHER M
权利人:UNIV MICHIGAN REGENTS; ALLEGHENY-SINGER RES INST; UNIV COLORADO STATE RES FOUND
摘要:The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.

专利号:US-7429616-B2
优先权日:2005-07-15
标 题 :Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds
发明人：BRABANDER JEF DE; JIANG XIN
权利人:UNIV TEXAS
摘要:The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: n nThe invention further provides processes for making the compounds, their synthetic intermediates, and for methods of using the compounds and their pharmaceutical compositions for the treatment of neoplastic diseases.

专利号:JP-S61103879-A
优先权日:1984-10-26
标题:Synthesis of optically active (+)-pedamide

专利号:JP-S6259272-A
优先权日:1985-09-10
标题 :Synthesis of pederic acid

专利号:US-2006024806-A1
优先权日:2003-11-14
标题 :Mycolactone locus: an assembly line for producing novel polyketides, therapeutic and prophylactic uses
发明人：STINEAR TIMOTHY P; COLE STEWART T; LEADLAY PETER F; SMALL PAMELA L; JOHNSON PAUL D; JENKIN GRANT A; DAVIES JOHN K; HAYDOCK STEPHEN F
权利人:STINEAR TIMOTHY P; COLE STEWART T; LEADLAY PETER F; SMALL PAMELA L; JOHNSON PAUL D; JENKIN GRANT A; DAVIES JOHN K; HAYDOCK STEPHEN F
摘要:The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.