📜2,3-吡啶二甲酸置于双氧水体系中,用 水 用作溶剂,化学反应 1.0H,以88%的收率获得氧烟酸 参考文献:多金属氧酸盐的有机盐:用于合成吡啶n-氧化物衍生物的新型高效催化剂 标题:多金属氧酸盐的有机盐:用于合成吡啶n-氧化物衍生物的新型高效催化剂 摘要:在多金属氧酸盐的三种有机盐的存在下,将吡啶衍生物催化n-氧化为相关的n-氧化物,包括两种杂多阴离子(tha)7.7 H 6.3 [nap 5 W 30 O 110 ],1和(thpa)7.5 H 6.5 [nap 5 W 30 O 110 ],2和一种异聚阴离子[tba] 2 [w 6 O 19](3),其中w为中心金属原子.催化剂(3)显示出最佳的催化活性.高度选择性的氧化使相关n氧化物的收率极佳,并且在吡啶环的2位脱羧.研究了一些操作变量的影响,例如温度,各种溶剂和反应时间.优化反应条件. Doi:10.1080/15533174.2010.522658
专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-8722852-B2 优先权日:2006-04-28 标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane 发明人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC 权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV 摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
专利号:US-6150403-A 优先权日:1997-10-14 标 题 :Topical compositions for regulating the oily/shiny appearance of skin 发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J 权利人:PROCTER & GAMBLE 摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.
专利号:US-2009155347-A1 优先权日:2006-04-28 标题 :Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:CA-2650578-A1 优先权日:2006-04-28 标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
参考标题:Microscale Parallel Synthesis Of Acylated Aminotriazoles Enabling The Development Of Factor Xiia And Thrombin Inhibitors 作者:Simon Platte,Marvin Korff,Lukas Imberg,Ilker Balicioglu,Catharina Erbacher,Jonas M. Will,Constantin G. Daniliuc,Uwe Karst,Dmitrii V. Kalinin |发布日期:2021.12.14 摘要:Approach Toward N-Acylated Aminotriazoles Is Reported, Enabling The Compounds' Screening Against Fxiia And Thrombin. This Approach Afforded Low-Nanomolar Fxiia And Thrombin Inhibitors With No Off-Targeting Of The Other Tested Serine Proteases. Selected Compounds Were Shown To Be Covalent Inhibitors Of Fxiia And Demonstrated Anticoagulant Properties In Vitro, Influencing The Intrinsic Blood Coagulation
合成参考文献
摘要:Puylaert, P.; Savini, A.; Hinze, S., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 346. 摘要:A. Foffani and U. Mazzucato. Ric. Sci. 26, 2409 (1956) ; CA 53, 823g. 摘要:J. S. Driscoll, W. Pfleiderer and E. C. Taylor, J. Org. Chem. 26, 5230 (1961). 摘要:A. N. Kost, P. B. Terentev, L. A. Golovleva and A. A. Stolyarchuk, Khim.-Farm. Zh. 1, 3 (1967); CA 68, 29556a.