CAS: 1970972-74-7; (R)-4-(1-((3-(Difluoromethyl)-1-Methyl-1H-Pyrazol-4-yl)Sulfonyl)-1-Fluoroethyl)-N-(Isoxazol-3-yl)Piperidine-1-Carboxamide

专利信息

专利号:US-2022289709-A1
优先权日:2019-07-16
标题:Polymorphic forms of (r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-(isoxazol-3-yl)piperidine-1-carboxamide
发明人：ZHONG MIN; MONNIER OLIVIER; JELIN JEAN-PHILIPPE; DUVOUX RICHARD; ALIE JEAN; OCHSENBEIN PHILIPPE
权利人:MYOKARDIA INC
摘要:The present invention provides novel polymorphs of (R)-4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide (I-491) that are useful for the treatment of cardiac disorders including systolic dysfunction, dilated cardiomyopathy (DCM), heart failure with reserved ejection fraction (HFrEF), and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the polymorphs is described, as well as methods for treating systolic dysfunction, DCM, HFrEF, and other forms of heart disease.

专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

专利号:US-11123337-B2
优先权日:2015-01-22
标题 :4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.