CAS: 160552-54-5; 4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One

• 英文名称4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One
• 中文名称拉米夫定杂质 H
• IUPAC名称4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
• 其它别名4-Amino-1-((2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-yl)Pyrimidin-2(1H)-One; 4-Amino-1-[(2R,3R,5S)-2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Pyrimidin-2(1H)-One-S-Oxide; Lamivudine Ep Impurity G; Lamivudine Impurity 8(Lamivudine Ep Impurity H); 2(1H)-Pyrimidinone,4-Amino-1-[(2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl]- (9Ci); 2(1H)-Pyrimidinone, 4-Amino-1-[(2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl]-; 4-Amino-1-[(2R,3R,5S)-2-(Hydroxymethyl)-3-Oxido-1,3-Oxathiolan-5-Yl]-2(1H)-Pyrimidinone; Lamivudine Ep Impurity H / R Sulfoxide
• CAS编号160552-54-5
• MFCD编号:MFCD23104278
• FDA UNII编号:3SN4QFF34D
• 分子式:C8H11N3O4S分子量:245.26
• 产品CID: 808092
• 同类组份化合物CAS134678-17-4160552-55-6 (sulfoxide)160552-54-5 (R-sulfoxide)131086-22-1 (±-trans)
• 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

• 相似结构搜索
• InChIKey: LJMQAXFNQNADRZ-AJHSIVBLSA-N
• InChI=1S/C8H11N3O4S/c9-5-1-2-11(8(13)10-5)6-4-16(14)7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+,16+/m0/s1
• 计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数2.0

物理性质

• 沸点601.7±65.0 °C at 760 mmHg
• 闪点317.7±34.3 °C
• 密度1.9±0.1 g/cm3
• pKa:13.46±0.10(预测)
• PSA:135.9
• LogP:-2.47
• 折射率1.818
• 蒸汽压0.0±3.9 mmHg at 25°C
• 溶解性DMSO (Slightly, Heated), Water (Slightly, Heated, Sonicated)
• 外观形态白色至类白色固体
• 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• 产品应用该化合物是LAMIVODINE的代谢物;一种强大的核核糖激素反转转抑制酶剂和抗病毒剂.

MSDS等安全信息

合成工艺路线路线简述

海关参考信息

• 2905310000-1,2-乙二醇
  2909110000-乙醚
  2930909099-其他有机硫化合物
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