专利号:WO-2006067109-A1 优先权日:2004-12-22 标 题 :Process for the mechanochemical synthesis of metal carboxylate 发明人:ROBIN JEAN-JACQUES; TIFFES DOMINIQUE; HANNECART ETIENNE 权利人:SOLVAY; ROBIN JEAN-JACQUES; TIFFES DOMINIQUE; HANNECART ETIENNE 摘要:Process for the mechanochemical synthesis of metal carboxylate Process for the mechanochemical synthesis of metal carboxylate, according to which, in a first stage, a mixture (M) comprising at least one acidic substance (A) selected from carboxylic acids and carboxylic acid anhydrides, at least one basic inorganic metal compound (B), water (C) and at least one third solid body (D) which is chemically inert with regard to the components (A), (B) and (C) and the metal carboxylate is formed and, in a second stage, the abovesaid mixture (M) is subjected to a mechanical stress sufficient to bring about a mechanochemical reaction between the acidic substance (A) and the basic inorganic metal compound (B).
专利号:US-6891059-B2 优先权日:2000-01-27 标题:Asymmetric synthesis of pregabalin 发明人:BURK MARK JOSEPH; GOEL OM PRAKASH; HOEKSTRA MARVIN SIMON; MICH THOMAS FREDERICK; MULHERN THOMAS; RAMSDEN JAMES A 权利人:WARNER LAMBERT CO 摘要:This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
专利号:US-4399240-A 优先权日:1981-12-30 标 题:Removal of acrylonitrile from latex with saturated heterocyclic amines 发明人:SENYEK MICHAEL L 权利人:GOODYEAR TIRE & RUBBER 摘要:Acrylonitrile is a monomer that is widely used in the synthesis of a vast variety of polymers. Undesirable quantities of unpolymerized residual acrylonitrile are often present in these acrylonitrile polymers. This residual or free acrylonitrile dissolved in an acrylonitrile polymer and/or its emulsifier system and the water phase used in its polymerization can be reduced significantly in concentration by treatment with saturated 6 to 7 membered ring heterocyclic amines. These amines react with acrylonitrile by a nitrogen-cyanoethylation reaction which results in the formation of a tertiary amino linkage.
专利号:US-4365027-A 优先权日:1981-12-28 标 题 :Removal of acrylonitrile from latex with oximes 发明人:SENYEK MICHAEL L; COSTANZA ALBERT J 权利人:GOODYEAR TIRE & RUBBER 摘要:Acrylonitrile is a monomer that is widely used in the synthesis of a vast variety of polymers. Undesirable quantities of unpolymerized residual acrylonitrile are often present in these acrylonitrile polymers. This residual or free acrylonitrile dissolved in an acrylonitrile polymer and/or its emulsifier system and the water phase used in its polymerization can be reduced significantly in concentration by treatment with oximes. Oximes react with acrylonitrile by an oxygen-cyanoethylation reaction which results in the formation of a cyanoethyl oximino ether linkage.
专利号:US-7501536-B2 优先权日:2005-01-19 标题 :Odorant compounds, synthesis method, and uses of said compounds 发明人:JAUNKY PIOTR; MANE JEAN; SCHROEDER MARTIN 权利人:MANE FILS V 摘要:A compound of general formula (I) with or without the double bond illustrated by the dotted line. In formula (I), X is a CHO, CH2OH, CH2OC(O)R or CH(OR)2 group, and R represents a linear or branched C1-C5 alkyl or alkenyl chain. The synthesis method for the compound, and especially the 6,8-dimethyl-non-7-enal (1) prepared by the hydroformylation of the 5,7-dimethyl-octa-1,6-diene is also disclosed, as well as compositions containing the compounds of formula (I). Due to the odorant properties thereof, the compounds are highly useful in perfumery, especially for cosmetic products and household products.
专利号:WO-2008009841-A1 优先权日:2006-07-18 标 题 :New odoriferous compounds, synthesis process and uses thereof 发明人:MANE JEAN; CHANOT JEAN-JACQUES; JAUNKY PIOTR; MARIN CHRISTOPHE 权利人:MANE FILS V; MANE JEAN; CHANOT JEAN-JACQUES; JAUNKY PIOTR; MARIN CHRISTOPHE 摘要:Compound of the general formula (I), wherein X is a group CHO, CH2OH, CH2OR, CH2OC(O)R or CH(OR1) (OR2) and each of R, R1, R2 represents an alkyl or alkylene chain having 1, 2, 3, 4, 5, or 6 carbon atoms, wherein said chain is linear or branched; or R1 and R2 together can form a cycle, preferably a cycle having 5 or 6 atoms and the bond illustrated by the dotted line is present or absent; synthesis process and use as odoriferous agent or masking agent for masking an odor.
[参考文献]: Pingxi Xu, Et Al. Mosquito Odorant Receptor For Deet And Methyl Jasmonate. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16592-7.
合成参考文献
摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 47, 1034. 摘要:Joó, F., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 109. 摘要:Journal of Pharmacy and Pharmacology., 21(85), 1969 []