CAS: 152121-30-7; 4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol
该化合物是一个合成有机化合物,其结构复杂,包括一个以各种芳香组群替代的imidazole环,其存在有助于其潜在的电子特性,而氢联苯混合物可能增强其溶解性和再活性.pyridyl替代成分在结构中引入氮,这会影响化合物的氢联结能力和总体极性.该化合物可能展示生物活动,使其对药用化学,特别是药品的开发具有兴趣.其独特的功能组组合表明在药物设计等领域的潜在应用,例如与生物目标的相互作用至关重要.此外,该化合物的稳定性,溶解性和再活性可能受到环境因素的影响,因此在实际应用中考虑这些特征非常重要.
- 英文名称4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol
- 中文名称杀虫畏
- IUPAC名称4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol
- CAS编号152121-30-7
- MFCD编号:MFCD00941964
- EINECS号:633-977-2
- FDA UNII编号:PVX798P8GI
- 分子式:C20H14FN3O分子量:331.35
- 产品CID: 744898
- 同类组份化合物CAS152121-30-7 (free base)350228-36-3 (HCl)
- 产品分类医药中间体 → 吡啶类化合物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号116332-54-8 N-甲基-N-甲氧基-4-氟苯甲酰胺 | CAS号117423-41-3 4-(叔丁基二甲基甲硅烷基氧基甲基)吡啶 | CAS号108-89-4 4-甲基吡啶 | CAS号6576-05-2 1-(4-氟苯基)-2-(4-... | CAS号403-43-0 对氟苯甲酰氯 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号152122-41-3 2-(tert-butyldi...合成工艺路线路线简述
- 合成目标产物 Sb 202190 主要起始原料 4-Fluorobenzoyl Chloride
- (文献来源)合成步骤主要原料 4-Fluorobenzoyl Chloride
📜1-(4-氟苯基)-2-(4-吡啶基)乙酮置于盐酸,Ammonium Acetate,溶剂黄146,Sodium Nitrite,亚磷酸三乙酯体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 22.5H,反应生成4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑
参考文献:Regulation Of Stress-Induced Cytokine Production By Pyridinylimidazoles; Inhibition Of Csbp Kinase
标题:Regulation Of Stress-Induced Cytokine Production By Pyridinylimidazoles; Inhibition Of Csbp Kinase
摘要:Members Of Three Classes Of Pyridinylimidazoles Bind With Varying Affinities To Csbp (P38) Kinase Which Is A Member Of A Stress-Induced Signal Transduction Pathway. Based Upon Sar And Protein Homology Modeling,The Pharmacophore And Three Potential Modes Of Binding To The Enzyme Are Presented. For A Subset Of Pyridinylimidazoles,Binding Is Shown To Correlate With Inhibition Of Csbp Kinase Activity,Whereas No Significant Inhibition Of Pka,Pkc Alpha And Erk Kinase Activity Is Observed. Copyright (C) 1997 Elsevier Science Ltd.
Doi:10.1016/s0968-0896(96)00212-X
海关参考信息
- 2933310010-吡啶
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8557837-B2
优先权日:2010-02-10
标题:Sinomenine derivatives, synthetic methods and uses thereof
发明人：YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO
权利人:YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO; SHANGHAI INST ORGANIC CHEM; SHANGHAI INST BIOL SCIENCES
摘要:The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: n n n n n n n n n n Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).
专利号:CN-101798285-A
优先权日:2010-02-10
标 题:A kind of sinomenine derivative, synthesis method and application thereof
专利号:CN-101798285-B
优先权日:2010-02-10
标 题 :A kind of sinomenine derivative, synthesis method and application thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095.
2: Shanware NP, Williams LM, Bowler MJ, Tibbetts RS. Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB Rep. 2009 Mar 31;42(3):142-7. doi: 10.5483/bmbrep.2009.42.3.142.
3: Glover M, Sweeny C, Davis B, O'Shaughnessy KM. A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190. Open Med Chem J. 2010 Sep 3;4:57-61. doi: 10.2174/1874104501004010057.
合成参考文献
参考文献:10.1016/j.toxlet.2011.06.029
摘要:Umannová L, Machala M, Topinka J, Schmuczerová J, Krčmář P, Neča J, Šujanová K, Kozubík A, Vondráček J. Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells. Toxicol Lett. 2011 Oct 10;206(2):121–9. doi: 10.1016/j.toxlet.2011.06.029.
参考文献:10.1016/j.cellsig.2011.07.002
摘要:Walters JN, Bickford JS, Beachy DE, Newsom KJ, Herlihy JH, Peck MV, Qiu X, Nick HS. cPLA2α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: A positive feedback loop. Cellular Signalling. 2011 Dec;23(12):1944–51. doi: 10.1016/j.cellsig.2011.07.002.
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