CAS: 1186-70-5; 1-Methoxy-N,N,N',N'-Tetramethylmethanediamine

上下游产品

CAS号124-41-4 甲醇钠 | CAS号2013-91-4 [(dimethylamino... | CAS号1071-38-1 (二甲氨基亚甲基)二甲基氯化铵 | CAS号2214-82-6 bis(dimethylami... | CAS号67-56-1 甲醇 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号124-40-3 二甲胺 | CAS号110-91-8 吗啉 | CAS号111725-60-1 3-(dimethylamin... | CAS号49633-25-2 3-异丙基吡唑 | CAS号632-22-4 四甲基脲 | CAS号28467-36-9 2-(dimethylamin... | CAS号1201-93-0 3-(二甲氨基)-1-苯基-2... | CAS号2802-08-6 1-二甲基呋喃-1-3-酮 | CAS号1187-27-5 2-氰基-3-(二甲基氨基)丙烯酸甲酯 | CAS号15802-80-9 3-叔丁基吡唑 | CAS号75039-59-7 2-Dimethylamino... | CAS号75471-07-7 N,N-dimethyl-1-...

📜Methanediamine,1-Chloro-N,N,N',N'-Tetramethyl-以 四氢呋喃 用作溶剂,化学反应 24.0H,反应生成二(二甲基氨基)甲氧基甲烷
参考文献:Shevchenko,I. V.; Furmanova,M. V.; Kukhar',V. P.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 6,P. 1289-1290
标题:Shevchenko,I. V.; Furmanova,M. V.; Kukhar',V. P.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 6,P. 1289-1290

专利信息

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:US-7323589-B2
优先权日:2000-10-26
标 题:Intermediates for use in retinoid synthesis
发明人：VALLA ALAIN; CARTIER DOMINIQUE; LABIA ROGER; POTIER PIERRE JEAN-PAUL
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH 3 ) 2 —, —N(C 2 H 5 ) 2 -group or N-pyrrolidine: n is an integer equal to 1 or 2: R 1 , R 2 and R 3 , independently of one another, represent a hydrogen atom or a methyl group, the successive unsaturated units capable of being moreover identical or different, provided that at least one of the substituents R 1 , R 2 and R 3 is different from H: and Y 1 and Y 2 represent each a —COOCH 3 group or a COOC 2 H 5 group.

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

专利号:EP-3464243-A2
优先权日:2016-05-30
标 题:An improved process for the synthesis of ivacaftor

专利号:WO-2017208253-A2
优先权日:2016-05-30
标 题:An improved process for the synthesis of ivacaftor

专利号:EP-4043439-A1
优先权日:2016-05-30
标 题 :An improved process for the synthesis of ivacaftor [