CAS: 118289-16-0; 2-Bromopyridine-4-Methanol

相似化合物

1289387-96-7 118289-17-1 26156-48-9

上下游产品

CAS号118289-17-1 2-溴吡啶-4-甲醛 | CAS号66572-56-3 2-溴吡啶-4-羧酸 | CAS号26156-48-9 2-溴吡啶-4-甲酸甲酯 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号4926-28-7 2-溴-4-甲基吡啶 | CAS号118289-17-1 2-溴吡啶-4-甲醛 | CAS号32938-44-6 2-溴-4-(溴甲基)吡啶氢溴酸盐 | CAS号83004-14-2 2-溴-4-(溴甲基)吡啶

2-溴-4-甲基吡啶置于potassium Permanganate,Lithium Aluminium Tetrahydride,氯甲酸乙酯,三乙胺体系中,用 水 用作溶剂,化学反应 1.5H,反应生成2-溴-4-吡啶甲醇
参考文献:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
标题:新型1,4-二氢吡啶类钙拮抗剂.I.4-(取代的吡啶基)-1,4-二氢吡啶衍生物的合成和降血压活性.
摘要:合成了一系列4-(取代的吡啶基)-1,4-二氢吡啶衍生物,并研究了它们的降压作用.几种化合物,2-(n-苄基-N-甲基氨基)乙基甲基1,4-二氢-2,6-二甲基-4-(3-硝基-2-吡啶基)-3,5-吡啶二甲酸(2B),4-(4-硝基-2-吡啶基)类似物(2G),4-(3-三氟甲基-2-吡啶基)类似物(2C),4-(2-三氟甲基-3-吡啶基)类似物(3E),4-发现(4-氰基-2-吡啶基)类似物(2E),4-(2-氰基-3-吡啶基)类似物(3D)和4-(6-溴-2-吡啶基)类似物(2I)具有与尼卡地平类似的降压活动;特别是2C和3E的持续时间约为尼卡地平的两倍,而2E具有在所有合成衍生物中最有效的降压活性.
Doi:10.1248/cpb.38.2446

专利信息

专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-9266848-B2
优先权日:2009-09-17
标题:4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
发明人：CLARY LAURENCE; PASCAL JEAN-CLAUDE
权利人:CLARY LAURENCE; PASCAL JEAN-CLAUDE; GALDERMA RES & DEV
摘要:The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I) below: and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.

专利号:CN-119912427-A
优先权日:2025-01-02
标题 :Synthesis method of 2-bromo-4- (piperidylmethyl) pyridine