CAS: 11116-32-8; 2-((2-(2-(6-Amino-2-(3-Amino-1-((2,3-Diamino-3-Oxopropyl)Amino)-3-Oxopropyl)-5-Methylpyrimidine-4-Carboxamido)-3-((5-((1-((2-(4-((3-((4-Aminobutyl)Amino)Propyl)Carbamoyl)-[2,4'-Bithiazol]-2'-yl)Ethyl)Amino)-3-Hydroxy-1-Oxobutan-2-yl)Amino)-3-Hydroxy-4-Methyl-5-Oxopentan-2-yl)Amino)-1-(1H-Imidazol-5-yl)-3-Oxopropoxy)-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-4-Yl Carbamate

该化合物是源自细菌* 脊椎结核* 的抗生素,主要以其抗肠素特性而闻名,用于治疗各种癌症,包括睾丸癌和霍格金淋巴瘤.该化合物展示了独特的行动机制,它涉及通过形成自由基来诱导DNA链断裂,最终导致细胞死亡.Bleomycin A5的特征是它能够与DNA结合,特别是谷氨残留物,其功效受氧浓度和金属离子存在等因素的影响.该物质通常通过注射进行,并可能造成副作用,包括肺毒性和皮肤反应.其结构包括一个独特的有金属约束力的领域,这对于其生物活动至关重要.

英文名称2-((2-(2-(6-Amino-2-(3-Amino-1-((2,3-Diamino-3-Oxopropyl)Amino)-3-Oxopropyl)-5-Methylpyrimidine-4-Carboxamido)-3-((5-((1-((2-(4-((3-((4-Aminobutyl)Amino)Propyl)Carbamoyl)-[2,4'-Bithiazol]-2'-yl)Ethyl)Amino)-3-Hydroxy-1-Oxobutan-2-yl)Amino)-3-Hydroxy-4-Methyl-5-Oxopentan-2-yl)Amino)-1-(1H-Imidazol-5-yl)-3-Oxopropoxy)-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-4-Yl Carbamate
中文名称对甲苯磺酸正丙酯
IUPAC名称2-((2-(2-(6-amino-2-(3-amino-1-((2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-((5-((1-((2-(4-((3-((4-aminobutyl)amino)propyl)carbamoyl)-[2,4'-bithiazol]-2'-yl)ethyl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino)-1-(1H-imidazol-5-yl)-3-oxopropoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate
其它别名N1-(3-((4-Aminobutyl)Amino)Propyl)Bleomycinamide; Pingyangmycin A5; Zhengguanmycin A5; Bleomycinamide, N1-[3-[(4-Aminobutyl)Amino]Propyl]-; Bleomycetin; Bleomycin A5; Bleomycin A5 Usp/ep/bp
CAS编号11116-32-8
MFCD编号:MFCD00869290
EINECS号:234-357-0
FDA UNII编号:5DY91Y7601
分子式:C57H89N19O21S2分子量:1440.58
产品CID: 148274
产品分类原料药 → 抗肿瘤药 → 抗生素类抗肿瘤药

相似结构搜索
InChIKey: QYOAUOAXCQAEMW-DDZPZTJXSA-N
InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44
计算化学: 氢键受体数33.0氢键供体数22.0可旋转键数40.0

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2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇
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专利信息

专利号:CN-114907388-A
优先权日:2022-05-18
标题:Synthesis of three-dimensional microporous cadmium compound and application of three-dimensional microporous cadmium compound in pesticide residue pymetrozine detection

专利号:CN-114907388-B
优先权日:2022-05-18
标题:Synthesis of three-dimensional microporous cadmium compound and application of three-dimensional microporous cadmium compound in pesticide residue pymetrozine detection

专利号:CN-115181061-A
优先权日:2022-06-21
标题:A kind of nickel compound, its synthesis method and its application in detecting pesticide residue glyphosate

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合成参考文献

摘要:Sun ML, Xie WH, Wang CM, Wen YM. [Lymphatic targeting study of pingyangmycin-activated carbon nanoparticles treating oral cancer lymph node metastasis]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2011 Jun;29(3):253–6, 263.