氢氰酸置于氯体系中,化学反应生成三聚氯氰 参考文献:Serullas,Annales De Chimie (Cachan,France),1828,Vol. <2>38,P. 384 标题:Serullas,Annales De Chimie (Cachan,France),1828,Vol. <2>38,P. 384
专利信息
专利号:US-6515039-B1 优先权日:1998-08-28 标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material 发明人:ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER 权利人:POLY AN GMBH 摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.
专利号:US-2004038331-A1 优先权日:2002-08-23 标题:Solid phase synthesis of biomolecule conjugates 发明人:REDDY M PARAMESWARA; FAROOQUI FIRDOUS; BRILLHART KURT L 摘要:Processes for the solid state phase formation synthesis of biomolecule conjugates, particularly protein-oligonucleotide conjugates are shown. One of the protein or oligonucleotide is reversibly bound to a solid substrate phase. At least one portion of each of the protein and the oligonucleotide molecules is activated with complementary activation groups. The activated protein and the activated oligonucleotide are then reacted, in a buffered solution resulting in the formation of the desired conjugate which remains reversibly bound to the substrate. The nature of the buffered solution is then modified causing the conjugate to be released from the substrate solid phase.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-3641020-A 优先权日:1969-01-23 标 题 :Synthesis of cyanuric fluoride 发明人:ANDERSON RICHARD W; FRICK HUGHIE R 权利人:DOW CHEMICAL CO 摘要:A PROCESS FOR THE EFFICIENT SYNTHESIS OF CYANURIC FLUORIDE IS PROVIDED. THE PROCESS COMPRISES CONTACTING CERTAIN CYANURIC HALIDES WITH SELECTED ALKALI METAL FLUORIDES IN THE PRESENCE OF A PERHALOCARBONYL COMPOUND. THE PROCESS OF THE PRESENT INVENTION PROVIDES FOR THE PRODUCTION OF CYANURIC FLUORIDE AT CONSIDERABLY REDUCED TEMPERATURES, THAN THOSE USED IN KNOWN PROCESSES.
专利号:US-9873153-B1 优先权日:2017-03-21 标 题 :Synthesis of metal nanoparticles using modified MPEG polymer 发明人:El-Faham Ayman Sadek Ahmed; AL OTHMAN ZEID ABDULLAH MOHAMMED; OSMAN SAMEH MOHAMED MAHMOUD 权利人:UNIV KING SAUD 摘要:The synthesis of metal nanoparticles using a modified mPEG (methoxypolyethylene glycol) polymer includes the steps of: preparing a methanolic solution of a polymer; providing an aqueous solution including a metal salt; and combining the methanolic solution of the polymer with the aqueous metal salt solution to produce the metal nanoparticles, where the metal salt is AgNO 3 , CuCl 2 , NiCl 2 , CoCl 2 , Pd(Ac) 2 , or HAuCl 4 and wherein the metal nanoparticles are silver, copper, cobalt, palladium, nicker or gold nanoparticles having a size between 1 nm and 100 nm in diameter.