CAS: 108-55-4; Dihydro-2H-Pyran-2,6(3H)-Dione

相似化合物

4166-53-4 4160-82-1 185815-59-2

上下游产品

CAS号2873-74-7 戊二酰氯 | CAS号110-94-1 戊二酸 | CAS号1670-46-8 2-乙酰环戊酮 | CAS号108-24-7 乙酸酐 | CAS号111-30-8 戊二醛 | CAS号64-19-7 冰醋酸 | CAS号102586-88-9 1,5-Ethano-1H-1... | CAS号82840-53-7 | CAS号82840-52-6 (1,2-bis(diphen... | CAS号2121-66-6 1,1,3,3-tetraet... | CAS号108046-33-9 1-苄基-3,4-二氢-1H-... | CAS号106754-06-7 5-(butylamino)-... | CAS号109418-98-6 Pentanoic acid,... | CAS号111211-54-2 (7CI,9CI)-3,4-二... | CAS号42856-43-9 N-苄基-2,6-哌啶二酮 | CAS号5105-78-2 N-苄氧羰基-4-氨基丁酸 | CAS号3543-74-6 5-[双(2-羟乙基)氨基]-... | CAS号3637-15-8 5-氧代壬酸 | CAS号59345-42-5 5-naphthalen-2-... | CAS号36978-49-1 5-(4-氯苯基)-5-氧代戊酸

戊二酸置于乙酸酐体系中,化学反应生成戊二酸酐
参考文献:远程载入脂质体的紫杉醇衍生物的合成及疗效改善
标题:远程载入脂质体的紫杉醇衍生物的合成及疗效改善
摘要:根据rb(Oh) 2与脂质体内水相不同束缚剂相互作用的特点,设计合成了一系列硼酸修饰的紫杉醇新型衍生物,用于开发远程难溶性药物载入.脂质体.同时,我们筛选了 19 种紫杉醇硼酸衍生物对三种癌细胞系(a549,Hct-116 和 4T1)和一种正常细胞系(lo2)的细胞毒活性,并对活性化合物进行了脂质体制剂筛选.在所有化合物中,4D的脂质体具有优异的药物包封率(>95%,药物脂质比为 0.1 W / W),是最稳定的.此外,化合物4D脂质体(8 Mg/kg,4次)和更高剂量化合物4D(24 Mg/kg,4次)对4T1肿瘤的治疗效果优于紫杉醇(8 Mg/kg,4次)体内模型,抑瘤率分别为74.3%,81.9%和58.5%.本研究为难溶性药物提高脂质体载药量和体内抗肿瘤作用提供了合理的设计策略.
Doi:10.3390/molecules27227967

专利信息

专利号:WO-2024151344-A9
优先权日:2022-11-18
标题:A device that enables the combinatorial synthesis of small molecule libraries
发明人：COPELAND Gregory; LIU JANE
权利人:BRT BIOTECHNOLOGIES INC
摘要:A device for the synthesis of small molecules on a substrate is provided. The device includes a synthesis plate with vias, and a microfluidic patterning plate with a series ot open-faced channels that can be aligned with the vias on the synthesis plate. The device may be used to synthesize combinatorial libraries of small molecules.

专利号:US-2007259917-A1
优先权日:2006-04-24
标题 :Processes for the synthesis of 3-isobutylglutaric acid
发明人：KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
权利人:KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P
摘要:Provided are processes for the synthesis of 3-isobutylglutaric acid, an intermediate in the synthesis of (S)-Pregabalin.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-8415510-B2
优先权日:2008-02-28
标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

专利号:US-8536375-B2
优先权日:2008-12-22
标题:Synthesis of obtaining modified polyethylene glycol intermediates
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.

专利号:US-2018297925-A1
优先权日:2015-10-12
标题 :Methods for total synthesis of resolvin e1
发明人：JAGTAP PRAKASH
权利人:SALZMAN LOVELACE INVEST LTD
摘要:Methods for total chemical synthesis of Resolvin E1 (RvE1) include Wittig reaction of two compounds having hydroxyl protecting group in the presence of a strong base, removal of the hydroxyl-protecting groups with a deprotecting reagent to produce a compound having an ester group, and hydrolysis of the ester group to obtain RvE1