CAS: 10389-65-8; (Boc-Cys-Oh)2

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L-胱氨酸置于三乙胺体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 8.0H,以87%的收率获得n,N'-双(叔丁氧羰基)-L-胱氨酸
参考文献:叔丁基 2-吡啶碳酸酯.一种用于氨基酸叔丁氧基羰基化的有用试剂
标题:叔丁基 2-吡啶碳酸酯.一种用于氨基酸叔丁氧基羰基化的有用试剂
摘要:叔丁基 2-吡啶基碳酸酯是一种稳定的结晶化合物,被发现在氨基酸的叔丁氧基羰基化中非常有效.
Doi:10.1246/cl.1984.237

专利信息

专利号:US-4913852-A
优先权日:1986-06-24
标题 :Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives
发明人：MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
权利人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
摘要:Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Δ-4-pregnene-3,20-dione or with derivatives of Δ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucocorticoidal and anti-inflammatory properties have been prepared and tested. Pharmaceutical compositions, medicaments containing them as well as their applications are claimed, particularly in the cutaneous and ophthalmic fields. ##STR1##

专利号:US-4212795-A
优先权日:1978-11-13
标题:Cyclization of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-4033940-A
优先权日:1975-11-12
标 题:Cyclization of peptides
发明人：HUGHES JOHN L; SEYLER JAY K; LIU ROBERT C
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing an amino terminal cystine residue and a cysteine residue located in a position within the amino acid sequence, to give a desired peptide, and placing such intermediate peptide in a solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace a molecule of cysteine from the amino terminal cysteine residue. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-4217268-A
优先权日:1978-07-20
标 题:Synthesis of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
摘要:A new peptide is disclosed which has biological activity of the same type as known calcitonins and which has a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.