CAS: 102297-41-6; Tert-Butyl (Pyridin-3-Ylmethyl)Carbamate

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20173-04-0 3731-52-0 63361-56-8

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📜Tert-Butyl (4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoroundecyl)Oxy(Pyridin-3-Ylmethyl)Carbamate置于tris(Acetonitrile)Tricarbonylmolybdenum(0)体系中,用 甲醇 用作溶剂,以60%的收率获得n-Boc-3-氨甲基吡啶
参考文献:新型氟标记氨当量的合成与应用
标题:新型氟标记氨当量的合成与应用
摘要:已经开发出一种新型的含氟标签的氨当量.它基于氮-氧键,可以通过钼络合物或二碘化sa无痕地裂解.描述了在合成脲,酰胺,磺酰胺和氨基甲酸酯中的应用.氟氮原子连接基团的范围以伊托必利的合成为例,伊托必利是一种用于治疗功能性消化不良的药物.借助于氟纯化方法合成了伊托必利,并以非常好的总收率和高纯度分离了产物.
Doi:10.1002/chem.200903178

专利信息

专利号:US-8076479-B2
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
发明人：CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI
权利人:CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI; SCHERING CORP
摘要:Disclosed is a process for the synthesis of compounds of Formula I n nby sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1,n n nwherein R 1 is a linear, branched, or cyclic alkyloxy functional group of the structure (—R 2a —OH), R 2a is a linear, branched or cyclic alkyl group, R 2 is a linear, branched or cyclic alkyl group, and R 3 is an alkylene-heterocycle, said process comprising forming intermediate compound of Formula E1 by reacting, in a refluxing reaction solvent selected from alcohols having 5 or less carbon atoms and mixtures of two or more thereof, a methanol solution of a salt of a 4-alkyl-3-amino-pyrazole compound of Formula C1,n n nwith a diamidization reagent selected from dimethylmalonate, monomethylmalonyl-chloride, and malonyl dichloride in the presence of a Lewis base having sufficient proton affinity to abstract a proton from the 1-position nitrogen on the pyrazole ring.

专利号:US-2008058518-A1
优先权日:2006-08-28
标 题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates

专利号:EP-2057166-B1
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives

专利号:US-7737159-B2
优先权日:2004-01-21
标 题:Antibacterial compounds
发明人：ANDERSON DAVID D; BEUTEL BRUCE A; COOPER CURT S; GU YU-GUI; HINMAN MIRA M; KALVIN DOUGLAS M; KEYES ROBERT F; SEARLE XENIA B; WAGNER ROLF
权利人:ABBOTT LAB
摘要:Bacterial protein synthesis-inhibiting compounds having formula (I) n n n n n n n n n n and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

专利号:RU-2056425-C1
优先权日:1984-04-09
标题:Cephalosporin derivatives or their pharmaceutically acceptable acid-additive salts and methods of their synthesis