CAS: 91832-40-5; (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(Hydroxyimino)Acetamido)-8-Oxo-3-Vinyl-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

上下游产品

CAS号104797-47-9 头孢地尼活性新酯 | CAS号79349-82-9 7-氨基-3-乙烯基-3-头孢... | CAS号696592-20-8 7-(Z)-[2-(2-ami... | CAS号1056963-31-5 benzhydryl 7-[2... | CAS号865411-26-3 N,N'-dicyclohex...

Potassium Syn-7-[2-(2-Aminothiazol-4-yl)-2-Hydroxyiminoacetamido]-3-Vinyl-3-Cephem-4-Carboxylate Dihydrate置于盐酸体系中,用 水 作为反应溶剂,化学反应 2.0H,以90%的收率获得产物头孢地尼
参考文献: Crystalline Forms Of Cefdinir Potassium[fr] Formes Cristallines De Cefdinir Potassium
标题: Crystalline Forms Of Cefdinir Potassium[fr] Formes Cristallines De Cefdinir Potassium
摘要:本发明涉及一种新颖的头孢地尼的晶体钾盐-头孢地尼钾四水合物,其制备方法,包括头孢地尼钾四水合物的制药组合物,以及使用头孢地尼钾四水合物治疗细菌感染的方法.此外,本发明还涉及头孢地尼钾二水合物和头孢地尼钾四水合物的混合物,其制备方法,包括该混合物的制药组合物,以及使用头孢地尼钾二水合物和头孢地尼钾四水合物的混合物治疗细菌感染的方法.此外,还涉及从头孢地尼钾四水合物中制备纯头孢地尼和头孢地尼钾二水合物的方法.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:WO-2005100367-A1
优先权日:2004-04-13
标 题 :Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins
发明人：KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH
权利人:RANBAXY LAB LTD; KUMAR YATENDRA; PRASAD MOHAN; SINGH KAPTAN; PRASAD ASHOK; RICHHARIYA SANTOSH
摘要:The present invention relates to crystalline intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins and processes for their preparation. In particular, the present invention relates to crystalline ylides of Formula I, processes for their preparation, and their use as an intermediate in thepreparation of 3-(2-substituted vinyl) cephalosporins.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:EP-2030975-A1
优先权日:2007-08-06
标 题:CEFDINIR synthesis process
发明人：MANCA ANTONIO; FILIPPI MAURO; SALA BRUNO MAURIZIO; MONGUZZI RICCARDO AMBROGIO; FOGLIATO GIOVANNI
权利人:ACS DOBFAR SPA
摘要:Cefdinir preparation by synthesis of new key intermediates, isolable as variously solvated species complexed with thiophosphoric acid derivatives or with phosphoric acid derivatives.