CAS: 915385-81-8; 3-(4-Chlorophenyl)-N-(Pyridin-4-Ylmethyl)Adamantane-1-Carboxamide

上下游产品

3-(4-Chlorophenyl)Adamantane-1-Carbonyl Chloride 1057292-87-1
3-(4-氯苯基)-1-金刚烷甲酸 3-(4-Chlorophenyl)Adamantane-1-Carboxylic Acid 56531-62-5
[3-(4-Chlorophenyl)-1-Adamantyl]-Imidazol-1-Ylmethanone 1057292-88-2

📜4-甲氨基吡啶,[3-(4-Chlorophenyl)-1-Adamantyl]-Imidazol-1-Ylmethanone 以 甲苯 作为反应溶剂,化学反应生成 3-(4-氯苯基)-N-(4-吡啶基甲基)金刚烷-1-甲酰胺
参考文献:Sphingosine Kinase Inhibitors
标题:Sphingosine Kinase Inhibitors
摘要:这项发明涉及替代金刚烷化合物,其药物组成部分,其制备过程,以及抑制神经鞘氨醇激酶,治疗或预防过度增殖性疾病,炎症性疾病或血管反应生成性疾病的方法.

专利信息

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.

专利号:CN-116217468-A
优先权日:2023-02-22
标题:Novel synthesis method of opanib