CAS: 777061-36-6; Tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-Indole-1-Carboxylate

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CAS号129822-48-6 5-氯-1H-吲哚-1-甲酸叔丁酯 | CAS号73183-34-3 双戊酰二硼 | CAS号182344-70-3 5-溴-1H-吲哚-1-甲酸叔丁酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号269410-24-4 5-吲哚硼酸频哪醇酯 | CAS号10075-50-0 5-溴吲哚 | CAS号17422-32-1 5-氯吲哚 | CAS号76-09-5 频哪醇 | CAS号317830-84-5 1-B°C-吲哚-5-硼酸 | CAS号317830-84-5 1-B°C-吲哚-5-硼酸 | CAS号129822-47-5 1-(tert-Butoxyc...

📜1-Boc-1H-吲哚-5-羧酸置于吡啶,Caesium Carbonate,N,N'-二环己基碳二亚胺体系中,用 乙酸乙酯 作为反应溶剂,化学反应 33.0H,反应生成 N-Boc-吲哚-5-硼酸频那酯
参考文献:芳基n-羟基邻苯二甲酰亚胺酯的无过渡金属,可见光使能的脱羧硼酰化
标题:芳基n-羟基邻苯二甲酰亚胺酯的无过渡金属,可见光使能的脱羧硼酰化
摘要:在此,我们报告了一种概念上新颖的硼酸化反应,该反应通过氧化还原活化的芳族羧酸的温和光诱导脱羧进行.这项工作构成了廉价且易于制备的 N-羟基邻苯二甲酰亚胺酯作为芳基自由基前体的首次应用,并且不需要使用昂贵的过渡金属或配体.该反应操作简单,可扩展,并显示出广泛的范围和官能团耐受性.
DOI:10.1021/jacs.7B03127

专利信息

专利号:US-2010022541-A1
优先权日:2006-09-25
标题:Chemical inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors
发明人：ESCAICH SONIA; DENIS ALEXIS; MOREAU FRANCOIS; GERUSZ VINCENT; DESROY NICOLAS
权利人:ESCAICH SONIA; DENIS ALEXIS; MOREAU FRANCOIS; GERUSZ VINCENT; DESROY NICOLAS
摘要:The invention relates to new compounds having heptose synthesis inhibitory properties, of formula (I) or a pharmaceutically acceptable salt, or prodrug thereof, wherein A is an aryl or heterocycle, optionally substituted by one or several identical or different R such as H, C1-C10 alkyl, C1-C10 alkyl-OR 1 , C1-C10 alkyl-NR 1 R 1 , alkoxy, hydroxy, thioalkyl, aryl, heterocycle, halogen, nitro, cyano, CO 2 R 1 , NR 1 R 1 , NR 1 C(O)R 1 , C(O)NR 1 R 1 , NR 1 C(S)R 1 , C(S)NR 1 R 1 , SO 2 NR 1 R 1 , SO 2 R 1 , NR 1 SO 2 R 1 , NR 1 C(O)NR 1 R 1 , NR 1 C(O)OR 1 , NR 1 C(S)NR 1 R 1 , NR 1 C(S)OR 1 , R 1 Câ•?NOR 1 , C(O)R 1 , aryloxy, thioaryl, alkenyl, alkynyl R1 identical or different is H or C1-C10 alkyl B 1 , B 2 , B 3 identical or not represent C, N, O, S to form a five-membered aromatic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from S, O, N optionally substituted by one or several identical or different R such as defined above B 4 is C or N Y is H, C1-C10 alkyl, alkoxy, thio-alkyl, optionally substituted by one or several identical or different R such as defined above W is C, O or N, substituted or not by one or several C1-C10 alkyl radicals D is an heterocycle optionally substituted by one or several identical or different R such as defined aboe.

专利号:EP-2104671-A2
优先权日:2006-09-25
标题:Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors

专利号:WO-2008038136-A2
优先权日:2006-09-25
标题 :Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors