CAS: 69922-27-6; 2-Fluoro-5-(Trifluoromethyl)Phenylisocyanate

相似化合物

16588-74-2 327-78-6 535-52-4

上下游产品

CAS号192819-46-8 1,3-Benzenediam... | CAS号32315-10-9 三光气

4-氟-N,N-二甲基-3-硝基苯胺置于palladium 10% On Activated Carbon 吡啶,氢气体系中,用 甲醇 作为反应溶剂,5.0~25.0 °C,500.01 Kpa 条件下,反应 18.5H,反应生成 2-氟-5-三氟甲基苯基异氰酸酯
参考文献:Substituted Indoles,Compositions Containing Them,Method For The Production Thereof And Their Use
标题:Substituted Indoles,Compositions Containing Them,Method For The Production Thereof And Their Use
摘要:式(I)的化合物:其中r1,R5,R6,R7,Ar,L,A和q如描述中所定义,并其盐,含有它们的组合物,制备它们的方法,以及它们作为药物的用途,特别是作为抗癌剂.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.