专利号:US-9938312-B2 优先权日:2011-03-25 标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans 发明人:BOONS GEERT-JAN; WANG ZHEN 权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA 摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
专利号:US-5229474-A 优先权日:1991-03-20 标题 :Synthesis of two-dimensional polymers by molecular recognition and chemical reaction among high molar mass monomers 发明人:STUPP SAMUEL I 权利人:UNIV ILLINOIS 摘要:A new variety of side chain liquid crystal polymers. The macromolecules of these materials are comb-shaped and differ from conventional side-chain liquid crystal polymers in that the comb's teeth are longer and semi flexible. The oligomeric side chains contain a long flexible spacer not only at their junction with the backbone but also in the center of the mesogen. Specific features of the systems include monosubstitution of enantiotopic protons in the central spacer by a cyano group and a long alkoxy tail at the terminus. An unusual property of these materials is a lower liquid crystal-isotropic transition temperature relative to that of their monomeric precursors.
专利号:WO-9101317-A1 优先权日:1989-07-19 标 题:Synthesis of cyclopentene derivatives 发明人:MYERS PETER LESLIE; STORER RICHARD; WILLIAMSON CHRISTOPHER 权利人:GLAXO GROUP LTD 摘要:A process is described for the preparation of the 1R-cis isomer of carbovir, [1'R,4'R]-2-amino-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-1,9-dihydro-6H-purin-6-one from carbocyclic guanosine via a cyclic orthoester of formula (III) (where R is a protecting group and R1 is a C¿1-6? alkyl group). The 1R-cis isomer of carbovir is an antiviral agent with potent activity against human immunodeficiency virus (HIV).
专利号:US-6559311-B1 优先权日:2001-10-30 标题 :Process for the synthesis of a photo-stabilizer 发明人:DESAI SHROJ AL MOHITKUMAR; SINGH RAJ PAL 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): n wherein R 1 is hydrogen, halogen, C 1 to C 12 alkyl, alkoxy (linear and branched), R 2 is hydrogen, C 1 -C 8 alkyl, cyclopentyl, cyclohexyl or cumyl, R 3 is hydrogen, C 1 -C 4 alkyl, R 4 is methyl or ethyl, R 5 is C 1 -C 8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C 1 -C 8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.
专利号:US-6072062-A 优先权日:1991-07-05 标 题 :Synthesis of C18 -modified vitamin D compounds and compounds resulting therefrom 发明人:VALLES MARIA J; MASCARENAS JOSEL; MOURINO ANTONIO; HALKES SEBASTIANUS J; ZORGDRAGER JAN 权利人:DUPHAR INT RES 摘要:The invention relates to a new vitamin D compound, substituted in the 18-position with an alkyl group, a hydroxy group, an alkoxy group, an alkenyl group, an alkynyl group, a fluorinated alkyl group or a fluorinated alkenyl group. The invention also relates to a method of preparing said vitamin D compound and to a lactone and a hydrindane intermediate. The vitamin D compound is of the general formula ##STR1##
专利号:US-5110926-A 优先权日:1989-07-19 标题:Process for the preparation of a carbocyclic nucleoside analogue 发明人:STORER RICHARD; MO CHI L; TURNBULL JOHN P 权利人:GLAXO GROUP LTD 摘要:A process is described for the preparation of carbocyclic guanosine from aristeromycin in a multi-step procedure, the final step of which is the hydrolysis of a compound of the formula ##STR1## wherein R 1 represents a C 1-6 alkyl group or an arylC 1-4 alkyl group and R 2 , R 3 and R 4 each independently represent a hydrogen atom or a hydroxyl protecting group. n Carbocyclic guanosine is an intermediate in the synthesis of carbocyclic analogues of nucleosides having use in therapy, particularly as antiviral agents.
[参考文献]: N Brasseur, Et Al. Synthesis And Photodynamic Activities Of Silicon 2,3-Naphthalocyanine Derivatives. J Med Chem. 1994 Feb 4;37(3):415-20.
合成参考文献
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