CAS: 67373-56-2; Chloro(2,3-Dimethylbutan-2-yl)Dimethylsilane

该化合物是一种专门有机硅化合物,主要用作有机合成中的一种悬浮剂,其受严格阻力的氧基组在保护羟基和其他功能组,特别是在复杂的分子框架中,加强了选择性,在保护氢氧基和其他功能组方面,特别是在复杂的分子框架中.该化合物与较少阻力的硅化氯相比,提供了更好的稳定性,减少了不必要的侧面反应.它的反作用性非常适合引入二甲基己酰硅(DMTS)保护组,这些保护组对酸性和基本条件具有抗药性,从而能够有选择地采取非保护战略.二甲基己酰硅氯化物在碳水化合物和核核克莱氏化学中特别有价值,因为精确的保护至关重要.该产品由于对湿度的敏感性,通常在不热条件下处理.

结构式图片

相似化合物

18162-48-6 71864-47-6

欧盟法规

ECHA物质C&L通报

上下游产品

2,3-Dimethyl-2-butene dimethylmon°Chlorosilane dimethyl-(1,1,2-trimethylpropyl)silanol hexamethylsilirane(2R,3S)-cis-3-dimethyl(1,1,2-trimethylpropyl)siloxy-1-vinylcyclohexa-4,6-diene-2-ol 16H26O2SiC16H26O2Si (1,1,2,2-tetramethyleth-1-yl)-dimethylsilyl trifluoromethanesulfonate oxy>benzene1-Bromo-3-oxybenzene

合成工艺路线路线简述

  • 合成目标产物 Dimethylthexylsilyl Chloride 主要起始原料 Chlorotrimethylsilane And 2,3-Dimethyl-2-Butene
  • (文献来源)合成步骤主要原料 Chlorotrimethylsilane 和 2,3-Dimethyl-2-Butene
Hexamethylsilirane置于盐酸体系中,用 四氢呋喃 作为反应溶剂,以90%的收率获得产物二甲基叔己基氯化硅
参考文献:六甲基甲硅烷基:Ii.一些简单试剂的开环反应
标题:六甲基甲硅烷基:Ii.一些简单试剂的开环反应
摘要:
DOI:10.1016/s0022-328X(00)86821-7

专利信息


专利号:US-9938312-B2
优先权日:2011-03-25
标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
发明人:BOONS GEERT-JAN; WANG ZHEN
权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA
摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.

专利号:US-5229474-A
优先权日:1991-03-20
标题 :Synthesis of two-dimensional polymers by molecular recognition and chemical reaction among high molar mass monomers
发明人:STUPP SAMUEL I
权利人:UNIV ILLINOIS
摘要:A new variety of side chain liquid crystal polymers. The macromolecules of these materials are comb-shaped and differ from conventional side-chain liquid crystal polymers in that the comb's teeth are longer and semi flexible. The oligomeric side chains contain a long flexible spacer not only at their junction with the backbone but also in the center of the mesogen. Specific features of the systems include monosubstitution of enantiotopic protons in the central spacer by a cyano group and a long alkoxy tail at the terminus. An unusual property of these materials is a lower liquid crystal-isotropic transition temperature relative to that of their monomeric precursors.

专利号:WO-9101317-A1
优先权日:1989-07-19
标 题:Synthesis of cyclopentene derivatives
发明人:MYERS PETER LESLIE; STORER RICHARD; WILLIAMSON CHRISTOPHER
权利人:GLAXO GROUP LTD
摘要:A process is described for the preparation of the 1R-cis isomer of carbovir, [1'R,4'R]-2-amino-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-1,9-dihydro-6H-purin-6-one from carbocyclic guanosine via a cyclic orthoester of formula (III) (where R is a protecting group and R1 is a C¿1-6? alkyl group). The 1R-cis isomer of carbovir is an antiviral agent with potent activity against human immunodeficiency virus (HIV).

专利号:US-6559311-B1
优先权日:2001-10-30
标题 :Process for the synthesis of a photo-stabilizer
发明人:DESAI SHROJ AL MOHITKUMAR; SINGH RAJ PAL
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): n wherein R 1 is hydrogen, halogen, C 1 to C 12 alkyl, alkoxy (linear and branched), R 2 is hydrogen, C 1 -C 8 alkyl, cyclopentyl, cyclohexyl or cumyl, R 3 is hydrogen, C 1 -C 4 alkyl, R 4 is methyl or ethyl, R 5 is C 1 -C 8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C 1 -C 8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.

专利号:US-6072062-A
优先权日:1991-07-05
标 题 :Synthesis of C18 -modified vitamin D compounds and compounds resulting therefrom
发明人:VALLES MARIA J; MASCARENAS JOSEL; MOURINO ANTONIO; HALKES SEBASTIANUS J; ZORGDRAGER JAN
权利人:DUPHAR INT RES
摘要:The invention relates to a new vitamin D compound, substituted in the 18-position with an alkyl group, a hydroxy group, an alkoxy group, an alkenyl group, an alkynyl group, a fluorinated alkyl group or a fluorinated alkenyl group. The invention also relates to a method of preparing said vitamin D compound and to a lactone and a hydrindane intermediate. The vitamin D compound is of the general formula ##STR1##

专利号:US-5110926-A
优先权日:1989-07-19
标题:Process for the preparation of a carbocyclic nucleoside analogue
发明人:STORER RICHARD; MO CHI L; TURNBULL JOHN P
权利人:GLAXO GROUP LTD
摘要:A process is described for the preparation of carbocyclic guanosine from aristeromycin in a multi-step procedure, the final step of which is the hydrolysis of a compound of the formula ##STR1## wherein R 1 represents a C 1-6 alkyl group or an arylC 1-4 alkyl group and R 2 , R 3 and R 4 each independently represent a hydrogen atom or a hydroxyl protecting group. n Carbocyclic guanosine is an intermediate in the synthesis of carbocyclic analogues of nucleosides having use in therapy, particularly as antiviral agents.
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主要参考文献

[参考文献]: N Brasseur, Et Al. Synthesis And Photodynamic Activities Of Silicon 2,3-Naphthalocyanine Derivatives. J Med Chem. 1994 Feb 4;37(3):415-20.

合成参考文献


参考文献:10.1007/s10661-005-7695-6
摘要:Jain N, Bhatia A, Kaushik R, Kumar S, Joshi HC, Pathak H. Impact of Post-Methanation Distillery Effluent Irrigation on Groundwater Quality. Environmental Monitoring and Assessment. 2005 Nov;110(1-3):243–55. doi: 10.1007/s10661-005-7695-6.
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