CAS: 527-52-6; D(+)-Digitoxose

上下游产品

CAS号71811-64-8 Methyl 2,3-anhy... | CAS号33650-60-1 methyl 3,4-di-O... | CAS号107908-90-7 methyl 2,6-dide... | CAS号3257-61-2 methyl 2,3-anhy... | CAS号17575-20-1 毛花洋地黄苷A | CAS号121576-17-8 O4'-β-Cellobios... | CAS号7664-93-9 硫酸 | CAS号69881-26-1 [6-methyl-4,5-b...

📜毛花苷c置于盐酸,水体系中,用 甲醇 作为反应溶剂,化学反应生成 头孢噻肟
参考文献:关于旧药物的新知识;一种洋地黄内酯型糖苷,具有细胞毒性作用和洋地黄的不常见次级代谢产物.
标题:关于旧药物的新知识;一种洋地黄内酯型糖苷,具有细胞毒性作用和洋地黄的不常见次级代谢产物.
摘要:对洋地黄(plantaginaceae)地上部分进行植物化学研究后,分离出未描述的心得宁类糖苷地高铁苷(1)以及五种已知化合物,分别为:栗子苷a(2),栗子苷b(3),氯苦素a(4),红景天苷(5)和山茱side苷(6)从其甲醇提取物中的水相中提取.分离的化合物的结构通过光谱技术确定.1-6是首次从d. Grandiflora中分离出来.这项研究首次从洋地黄属和车前草科报道了2和3.这是第二个关于洋地黄种发生4的报告.还测试了水部分的细胞毒性活性对hep-2(人类喉表皮样癌)和hepg2(人类肝细胞癌)癌细胞系以及l929(小鼠成纤维细胞)非癌细胞系的影响.水部分对hep-2细胞的毒性比hepg2强.因此,针对hep-2和l929细胞系测试了1,2,4和6的细胞毒性活性.由于数量不足,无法测试3和5.与阳性对照,依托泊苷和2-6(依托泊苷的ic50; 39.5μm)相比,图1显示了对he
DOI:10.1016/j.Fitote.2019.02.001

专利信息

专利号:US-2024117398-A1
优先权日:2021-01-20
标 题:Production of oligosaccharides comprising ln3 as core structure in host cells
发明人：AESAERT SOFIE; BEAUPREZ JOERI; PETERS GERT; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:Described is a method of producing an oligosaccharide comprising a lacto-N-triose (LN3; GlcNAc-beta1,3-Gal-beta1,4-Glc) as a core trisaccharide by cultivation with a genetically modified cell, as well as the genetically modified cell used in the method. The genetically modified cell comprises at least one nucleic acid sequence coding for a galactoside beta-1,3-N-acetylglucosaminyltransferase and a glycosyltransferase involved in the synthesis of an oligosaccharide comprising LN3 as a core trisaccharide and at least one nucleic acid sequence expressing a membrane protein. Furthermore, the present invention provides for a purification of the oligosaccharide comprising LN3 as a core trisaccharide from the cultivation.

专利号:US-2024191270-A1
优先权日:2021-04-16
标 题 :Fermentative production
发明人：BEAUPREZ JOERI; COUSSEMENT PIETER; DECOENE THOMAS
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of metabolically engineered cells and use of said cell in a cultivation, preferably a fermentation. The present invention describes a cell for the production of a compound. The cell comprises a pathway for the production of the compound, which can be a disaccharide, oligosaccharide and/or a Neu(n)Ac-containing bioproduct, wherein (n) is 4, 5, 7, 8 or 9 or a combination thereof. The cell is metabolically engineered for enhanced synthesis of acetyl-Coenzyme A. The invention also resides in a method of producing such compound by cultivation, preferably a fermentation, with such a cell.

专利号:US-2022403431-A1
优先权日:2020-02-14
标 题 :Glycominimized bacterial host cells
发明人：BEAUPREZ JOERI; DE MAESENEIRE SOFIA; SNOECK NICO
权利人:INBIOSE NV
摘要:This disclosure is in the technical field of synthetic biology and metabolic engineering. The disclosure provides engineered viable bacteria having a reduced or abolished synthesis of poly-N-acetyl-glucosamine (PNAG), Enterobacterial Common Antigen (ECA), cellulose, colanic acid, core oligosaccharides, Osmoregulated Periplasmic Glucans and Glucosylglycerol (O), glycan, and trebalose. The disclosure further provides methods for the production of bioproduct by the viable bacteria and uses thereof. Furthermore, the disclosure is in the technical field of fermentation of metabolically engineered microorganisms producing bioproduct.

专利号:US-2023174991-A1
优先权日:2020-02-14
标题 :Kdo-free production hosts for oligosaccharide synthesis
发明人：BEAUPREZ JOERI; COUSSEMENT PIETER; PETERS GART
权利人:INBIOSE NV
摘要:This disclosure relates to the technical field of synthetic biology and metabolic engineering. More particularly, this disclosure relates to the technical field of fermentation of metabolically engineered microorganisms. This disclosure describes engineered micro-organisms that produce oligosaccharides that are free of KDO-lactose impurities and/or KDO-oligosaccharide impurities.