专利号:WO-2009104605-A1 优先权日:2008-02-18 标 题 :Novel intermediate for synthesis of ascofranone having various physiological activities, and novel shortened total synthesis method for ascofranone using the same 发明人:SAIMOTO HIROYUKI; HAGA YASUSHI 权利人:ARIGEN PHARMACEUTICALS INC; SAIMOTO HIROYUKI; HAGA YASUSHI 摘要:In the synthesis of ascofranone, a compound represented by formula (III), (IV), (V) or (VII) or an optical isomer thereof is used as an intermediate for the synthesis. [In the formulae, R 1 and R 2 independently represent a hydrogen atom, a C 1-7 alkyl group, a phenoxyalkyl group having a halogen atom on a carbon atom in a benzene ring therein, or a phenyl group having a C 1-7 alkoxy group or a C 1-7 alkoxycarbonyl group on a carbon atom in a benzene ring therein; and X represents a halogen atom or a group R 5 SO 3 (wherein R 5 represents a C 1-7 alkyl group or a phenyl group having a C 1-7 alkyl group on a carbon atom in a benzene ring therein).] By using the compound, it becomes possible to reduce the number of steps required for the total synthesis of ascofranone to 7 or 8 from 12 which is a number of the steps required for the conventional ascofranone total synthesis processes.
专利号:US-5139940-A 优先权日:1989-10-26 标题 :Activation compounds and methods of synthesis of activation compounds 发明人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W 权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W 摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-10981850-B2 优先权日:2019-04-15 标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives 发明人:PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V 权利人:UNIV BOSTON 摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
专利号:US-12234203-B2 优先权日:2020-03-12 标 题:Process for the synthesis of cannabidiol and intermediates thereof 发明人:ANAND RADHIKA; SHARMA SUMIT; SINGH CHAM PANKAJ; GANNEDI VEERANJANEYULU; KUMAR MUKESH; PRATAP SINGH VARUN; PRAKASH RAHUL VISHAV; ASREY VISHWAKARMA RAM; PAL SINGH PARVINDER 权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF T; COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S 摘要:The present invention relates to process for the preparation of cannabidiol (A) from the coupling of (D) and (E) through the intermediates (C) and (D) starting from compound (B). The invention further relates to the novel compounds (B), (C), (D) and (E) and reagents used in this process. More specifically, this invention provides the manufacturing of Cannabidiol (A) in milligram to gram or kilogram scale.
专利号:WO-9108748-A1 优先权日:1989-12-13 标题 :Synthesis of rotavirus receptor saccharides 发明人:ABBAS SAEED A; NASHED MINA A; DASGUPTA FALGUNI; SRNKA CHERYL A; LAINE ROGER A 权利人:GLYCOMED INC 摘要:Saccharides which are active as rotavirus receptor sites are disclosed. These saccharides are synthetically produced sugar derivatives recognized by the antireceptor of a rotavirus. The molecules are useful in studying the interaction between the rotavirus antireceptor and most receptor sites so as to develop drugs useful in blocking the connection between such viruses and the host cells. Further, the molecules can be modified in order to increase the degree to which they attract the antireceptor sites of the virus and/or modified by binding to them antiviral compounds which are effective in destroying the virus once the receptor molecule binds to the virus. Synthetic receptor molecules recognizable by a rotavirus are obtainable by the synthesis methods disclosed.
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合成参考文献
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